Association of Methylenetetrahydrofolate Reductase Gene C677T Polymorphism With Multiple Sclerosis in Turkish Patients
Yazarlar (6)
Prof. Dr. Betül ÇEVİK Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Serbulent Yigit Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Doç. Dr. Nevin KARAKUŞ Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Prof. Dr. Dürdane AKSOY Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Semiha Kurt
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Omer Ates Tokat Gaziosmanpaşa Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | J Investig Med (Q4) | ||
| Dergi ISSN | 1708-8267 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2014 |
| Cilt / Sayı / Sayfa | 62 / 8 / 980–984 | DOI | 10.1097/JIM.0000000000000107 |
| Özet |
| Background and AimMultiple sclerosis (MS) is a chronic neurodegenerative autoimmune disease of the central nervous system. Genetic risk factors are known to contribute to the etiology of MS. Methylenetetrahydrofolate reductase (MTHFR) gene C677T polymorphism has been associated with susceptibility to various autoimmune diseases. The aim of this study was to investigate a possible association between the MTHFR gene C677T polymorphism and MS in Turkish patients.MethodsThe study included 130 MS patients and 150 group-matched controls. Genomic DNA was isolated and genotyped using polymerase chain reaction–based restriction fragment length polymorphism assay for the MTHFR gene exon C677T polymorphism.ResultsThe genotype and allele frequencies of C677T polymorphism showed statistically significant differences between MS patients and controls (P = 0.002 and P = 0.002; odds … |
| Anahtar Kelimeler |
| C677T | Gene polymorphism | MTHFR | Multiple sclerosis | Susceptibility |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Google Scholar | 22 |
| Scopus | 7 |
| Web of Science | 14 |