Association of MTHFR gene C677T mutation with recurrent aphthous stomatitis and number of oral ulcers
Yazarlar (3)
Göknur Kalkan Yıldırım Beyazıt Üniversitesi, Türkiye
Doç. Dr. Nevin KARAKUŞ Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Serbülent Yiğit Tokat Gaziosmanpaşa Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Clinical Oral Investigations (Q4) | ||
| Dergi ISSN | 1432-6981 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 03-2014 |
| Cilt / Sayı / Sayfa | 18 / 2 / 437–441 | DOI | 10.1007/s00784-013-0997-0 |
| Makale Linki | http://link.springer.com/10.1007/s00784-013-0997-0 | ||
| Özet |
| ObjectivesRecurrent aphthous stomatitis (RAS) is a common ulcerative disease of the oral mucosa. Methylenetetrahydrofolate reductase (MTHFR) gene variants are associated with thrombophilia and vasculopathy that may result in oral ulceration. Oral ulcers are also the most common feature of Behcet’s disease (BD). Association of MTHFR gene C677T mutation with BD has been reported in different populations. The aim of the present study was to investigate the possible association between MTHFR gene C677T mutation and RAS and evaluate if there was an association with clinical features in a relatively large cohort of Turkish patients.Materials and methodsThe study included 188 patients affected by RAS and 200 healthy controls. Genomic DNA was isolated and genotyped using polymerase chain reaction (PCR)-based restriction fragment length polymorphism (RFLP) assay for the MTHFR gene C677T … |
| Anahtar Kelimeler |
| C677T | Genetic susceptibility | MTHFR gene | Recurrent aphthous stomatitis (RAS) |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Google Scholar | 23 |
| Web of Science | 8 |