Effects of interleukin IL 6 gene polymorphisms on recurrent aphthous stomatitis
Yazarlar (5)
Doç. Dr. Nevin KARAKUŞ Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Serbülent Yiğit Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Aydın Rüstemoğlu Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Göknur Kalkan Yıldırım Beyazıt Üniversitesi, Türkiye
Dr. Öğr. Üyesi Nihan BOZKURT Tokat Gaziosmanpaşa Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Archives of Dermatological Research (Q4) | ||
| Dergi ISSN | 0340-3696 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 03-2014 |
| Cilt / Sayı / Sayfa | 306 / 2 / 173–180 | DOI | 10.1007/s00403-013-1406-x |
| Makale Linki | http://link.springer.com/10.1007/s00403-013-1406-x | ||
| Özet |
| Recurrent aphthous stomatitis (RAS) is a common disease with oral ulceration in which cytokines are thought to play an important role. High levels of interleukin (IL)-6, a pro-inflammatory cytokine have been detected in the circulation of ulcer tissue. The purpose of the present study was to investigate if the IL-6 gene polymorphisms are associated with RAS or clinical characteristics of RAS in a cohort of Turkish population. 184 RAS patients and 150 healthy controls were included in the study. The genotypes of IL-6 gene −572G>C and −174G>C polymorphisms were determined using polymerase chain reaction based restriction fragment length polymorphism analysis. The genotype frequencies of −572G>C polymorphism showed statistically significant differences between RAS patients and controls (p = 0.01). Frequencies of GG + GC genotypes and G allele of −572G>C polymorphism were found higher in RAS … |
| Anahtar Kelimeler |
| Cytokine | Genetic susceptibility | Interleukin (IL)-6 | Oral ulceration | Recurrent aphthous stomatitis (RAS) |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Google Scholar | 59 |
| Scopus | 2 |
| Web of Science | 33 |