DD genotype of ACE gene I D polymorphism is associated with Behcet disease in a Turkish population
Yazarlar (9)
Tokat Gaziosmapasa University, Türkiye
Ondokuz Mayis Üniversitesi, Türkiye
Tokat Gaziosmapasa University, Türkiye
Tokat Gaziosmapasa University, Türkiye
Ankara Numune Education And Research Hospital, Türkiye
Tokat Gaziosmapasa University, Türkiye
Tokat Gaziosmapasa University, Türkiye
Doç. Dr. Nevin KARAKUŞ
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Tokat Gaziosmapasa University, Türkiye
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | Molecular Biology Reports |
| Dergi ISSN | 0301-4851 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI |
| Dergi Grubu | Q4 |
| Makale Dili | İngilizce |
| Basım Tarihi | 01-2013 |
| Cilt No | 40 |
| Sayı | 1 |
| Sayfalar | 365 / 368 |
| DOI Numarası | 10.1007/s11033-012-2069-y |
| Özet |
| Behcet's disease (BD) is a chronic, multi-systemic and inflammatory disorder. The local renin-angiotensin system (RAS) in the vessel wall plays a role in the endothelial control and contributes to inflammatory processes. Angiotensin-converting enzyme (ACE) is the regulatory component of the RAS. This study was conducted in Turkish patients with BD to determine the frequency of I/D polymorphism genotypes of ACE gene. Genomic DNA obtained from 566 persons (266 patients with BD and 300 healthy controls). ACE gene I/D polymorphism genotypes were determined using polymerase chain reaction using I and D allele-specific primers. There was statistically significant difference between the groups with respect to genotype distribution (p<0.001). This study is the largest study in Turkish population that ACE gene I/D polymorphism investigated in BD. As a result of this study, ACE gene I/D polymorphism DD genotype could be a genetic marker in BD in Turkish study population. © 2012 Springer Science+Business Media Dordrecht. |
| Anahtar Kelimeler |
| Angiotensin-converting enzyme | Behcet's disease | Polymorphism |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| WoS | 14 |
| SCOPUS | 14 |
| Google Scholar | 20 |