Methylenetetrahydrofolate reductase C677T mutation in patients with alopecia areata in Turkish population
Yazarlar (7)
Goknur Kalkan Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Serbulent Yigit Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Doç. Dr. Nevin KARAKUŞ Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Omer Ates Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Dr. Öğr. Üyesi Nihan BOZKURT Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Atiye Ozdemir Tokat State Hospital, Türkiye
Gunseli Sefika Pancar Tokat State Hospital, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Gene (Q4) | ||
| Dergi ISSN | 0378-1119 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI | ||
| Makale Dili | İngilizce | Basım Tarihi | 11-2013 |
| Cilt / Sayı / Sayfa | 530 / 1 / 109–112 | DOI | 10.1016/j.gene.2013.08.016 |
| Özet |
| ObjectiveMethylene-tetrahydrofolate reductase (MTHFR) is a key enzyme regulating folate metabolism and it is thought to influence DNA methylation and nucleic acid synthesis. Mutations in the MTHFR gene have been associated with several autoimmune disorders in previous studies. Alopecia areata (AA) is considered to be a tissue-specific autoimmune disease as the hair follicle has been targeted and antibodies to their own hair follicle structures have been developed. Since there is a common shared pathway between AA and other autoimmune disorders, we aimed to investigate a possible association between the MTHFR gene C677T mutation and AA susceptibility in the Turkish population.MethodsThe study included 136 patients affected by AA and 130 healthy controls. Genomic DNA was isolated and genotyped using a polymerase chain reaction (PCR)-based restriction fragment length polymorphism … |
| Anahtar Kelimeler |
| Alopecia areata | C677T mutation | MTHFR gene |
Science Direct
Methylenetetrahydrofolate reductase C677T mutation in patients with alopecia areata in Turkish population
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Google Scholar | 23 |
| Scopus | 1 |
| Web of Science | 13 |