Branch Selective Synthesis of Oxindole and Indene Scaffolds Transition Metal Controlled Intramolecular Aryl Amidation Leading to C3 Reverse Prenylated Oxindoles

A, Ignatenko Vasily; DELİGÖNÜL, NİHAL; Rajesh, Viswanathan

doi:10.1021/ol1012372

Branch Selective Synthesis of Oxindole and Indene Scaffolds Transition Metal Controlled Intramolecular Aryl Amidation Leading to C3 Reverse Prenylated Oxindoles

Yazarlar (3)

Ignatenko Vasily A
Case Western Reserve University

Prof. Dr. Nihal DELİGÖNÜL Gaziosmanpaşa Üniversitesi, Türkiye

Viswanathan Rajesh
Case Western Reserve University

Makale Türü	Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
Dergi Adı	Organic Letters (Q4)
Dergi ISSN	1523-7060 Wos Dergi Scopus Dergi
Dergi Tarandığı Indeksler	SCI-Expanded
Makale Dili	İngilizce	Basım Tarihi	08-2010
Cilt / Sayı / Sayfa	12 / 16 / 3594–3597	DOI	10.1021/ol1012372
Makale Linki	http://pubs.acs.org/doi/abs/10.1021/ol1012372

Özet

In an effort to access biologically important scaffolds, a concise branch-selective synthesis of C3 tertiary oxindoles by Cu(I)-catalyzed aryl amidation and 2,2-dimethyl indene by Pd(0)-catalyzed Heck cyclization has been accomplished from acyclic reverse-prenylated intermediates. Oxindole C3-enolate generation using NaH followed by alkylation in the presence of appropriate electrophiles provides a novel route to quaternary C3 reverse-prenylated oxindoles.

Anahtar Kelimeler

BM Sürdürülebilir Kalkınma Amaçları

Atıf Sayıları
Google Scholar	41
Scopus	1
Web of Science	31

Branch Selective Synthesis of Oxindole and Indene Scaffolds Transition Metal Controlled Intramolecular Aryl Amidation Leading to C3 Reverse Prenylated Oxindoles

Dergi Adı	ORGANIC LETTERS
Yayıncı	American Chemical Society
Açık Erişim	Hayır
ISSN	1523-7060
E-ISSN	1523-7052
CiteScore	9,3
SJR	1,245
SNIP	1,020

Branch Selective Synthesis of Oxindole and Indene Scaffolds Transition Metal Controlled Intramolecular Aryl Amidation Leading to C3 Reverse Prenylated Oxindoles

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