Cyclometalated Iridium III Complexes with Deoxyribose Substituents
Yazarlar (6)
Case Western Reserve University, Amerika Birleşik Devletleri
Cleveland State University, Amerika Birleşik Devletleri
Massachusetts Institute Of Technology, Amerika Birleşik Devletleri
Prof. Dr. Nihal DELİGÖNÜL
Case Western Reserve University, Amerika Birleşik Devletleri
Cleveland State University, Amerika Birleşik Devletleri
Case Western Reserve University, Amerika Birleşik Devletleri
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | Chemistry A European Journal |
| Dergi ISSN | 0947-6539 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI |
| Dergi Grubu | Q4 |
| Makale Dili | İngilizce |
| Basım Tarihi | 11-2013 |
| Cilt No | 19 |
| Sayı | 47 |
| Sayfalar | 15924 / 15932 |
| DOI Numarası | 10.1002/chem.201301776 |
| Makale Linki | http://doi.wiley.com/10.1002/chem.201301776 |
| Özet |
| Fundamental study of enzymatic nucleoside transport suffers for lack of optical probes that can be tracked noninvasively. Nucleoside transporters are integral membrane glycoproteins that mediate the salvage of nucleosides and their passage across cell membranes. The substrate recognition site is the deoxyribose sugar, often with little distinction among nucleobases. Reported here are nucleoside analogues in which emissive, cyclometalated iridium(III) complexes are "clicked" to C-1 of deoxyribose in place of canonical nucleobases. The resulting complexes show visible luminescence at room temperature and 77 K with microsecond-length triplet lifetimes. A representative complex is crystallographically characterized. Transport and luminescence are demonstrated in cultured human carcinoma (KB3-1) cells. |
| Anahtar Kelimeler |
| click chemistry | fluorescent probes | iridium | metalation | nucleobases |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| WoS | 27 |
| SCOPUS | 29 |
| Google Scholar | 42 |