Clinical symptoms in fibromyalgia are associated to catechol O methyltransferase COMT gene Val158Met polymorphism
Yazarlar (7)
Türkiye
Doç. Dr. Nevin KARAKUŞ
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Prof. Dr. Hacı Ömer ATEŞ
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Malatya Turgut Özal Üniversitesi, Türkiye
Dr. Öğr. Üyesi Nihan BOZKURT
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Türkiye
Ondokuz Mayıs Üniversitesi, Türkiye
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | Xenobiatica. |
| Dergi ISSN | 0049-8254 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q4 |
| Makale Dili | İngilizce |
| Basım Tarihi | 10-2014 |
| Cilt No | 44 |
| Sayı | 10 |
| Sayfalar | 952 / 956 |
| DOI Numarası | 10.3109/00498254.2014.913083 |
| Özet |
| 1. Fibromyalgia syndrome (FMS) is a common chronic widespread pain syndrome mainly affecting women. The aim of this study was to explore the frequency and clinical significance of catechol-O-methyltransferase (COMT) gene Val158Met polymorphism in a large cohort of Turkish patients with FMS. 2. The study included 379 FMS patients and 290 controls. Genomic DNA was isolated and genotyped using polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) analyses. 3. The genotype frequencies of Val158Met polymorphism showed a small difference between FMS patients and healthy controls (p = 0.047), however, the Met/Met genotype was significantly higher in FMS patients than healthy controls (p = 0.016). No difference was observed for allele frequencies between two groups. Stratification analysis according to clinical features for this disease reveals that weight, FMS Impact Questionnaire score, algometry and Raynaud's syndrome, were detected to have statistically significant associations with Val158Met polymorphism (p = 0.037, p = 0.042, p = 0.039 and p = 0.033, respectively). Pain sensitivity, measured by algometry, was statistically higher in patients with Met/Met genotype than the patients with Val/Val and Val/Met genotypes (p = 0.017). 4. The results of this study suggested that COMT gene Val158Met polymorphism is positively associated with FMS and play a relevant role in the clinical symptoms of the disease. |
| Anahtar Kelimeler |
| Catechol-O-methyltransferase | fibromyalgia | pain | Val158Met polymorphism |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| WoS | 17 |
| Google Scholar | 32 |