Mildly Decreased Glomerular Filtration Rate is Associated with Poor Coronary Collateral Circulation in Patients with Coronary Artery Disease      
Yazarlar (7)
Hasan Kadı
Balıkesir Üniversitesi, Türkiye
Köksal Ceyhan
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Erkan Söğüt
İzmir Katip Çelebi Üniversitesi, Türkiye
Fatih Koç
Akdeniz Üniversitesi, Türkiye
Prof. Dr. Ataç ÇELİK Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Orhan Önalan
Karabük Üniversitesi, Türkiye
Şemsettin Şahin
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Makale Türü Açık Erişim Özgün Makale
Makale Alt Türü SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale
Dergi Adı CLINICAL CARDIOLOGY
Dergi ISSN 0160-9289 Wos Dergi Scopus Dergi
Dergi Tarandığı Indeksler SSCI
Dergi Grubu Q4
Makale Dili İngilizce
Basım Tarihi 01-2011
Cilt No 34
Sayı 10
Sayfalar 617 / 621
DOI Numarası 10.1002/clc.20951
Özet
Background: The aim of this study was to evaluate the association between mildly decreased glomerular filtration rate (GFR) and coronary collateral circulation (CCC). Hypothesis: There would be an association between mildly decreased GFR and CCC. Methods: Patients who had an occlusion in at least 1 major coronary artery were included in this study. Patients with severely and moderately decreased GFR were excluded. Patient data were obtained from their files. To classify CCC, we used the Rentrop classification. Patients were classified as having poor CCC (Rentrop grades 0 to 1) or good CCC (Rentrop grades 2 to 3). We used the Modification of Diet in Renal Disease (MDRD) equation to calculate GFR. Mildly decreased GFR was defined as 60 mL/min per 1.73 m 2 ≥ eGFR ≤89 mL/min per 1.73 m 2 according to the MDRD definition. Multivariate logistic regression analysis was performed to determine independent variables. Results: The study group consisted of 299 patients. Ninety-three patients had poor CCC and 206 patients had good CCC. The frequency of mildly decreased GFR was higher in the poor CCC group than in the good CCC group (P<0.001). Also, the frequency of diabetes and dyslipidemia, and the plasma high sensitive C-reactive protein levels, were higher in the poor CCC group (P = 0.003, P = 0.018, P < 0.001, respectively). Logistic regression analysis revealed that eGFR is an independent predictor of CCC (B = 1.68; odds ratio = 5.4 P < 95% confidence interval, 3.1-9.4). Conclusions: We found that CCC was worse in patients with mildly decreased GFR compared to patients with normal GFR in patients with coronary artery disease. © 2011 Wiley Periodicals, Inc.
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