The comparative cardiovascular pulmonary ocular blood flow and ocular hypotensive effects of topical travoprost bimatoprost brimonidine and betaxolol
 
Yazarlar (8)
Ümit Ubeyt Inan
Afyon Kocatepe Üniversitesi Tıp Fakültesi, Türkiye
Sitki Samet Ermis Afyon Kocatepe Üniversitesi Tıp Fakültesi, Türkiye
Ayse Orman
Afyon Kocatepe Üniversitesi Tıp Fakültesi, Türkiye
Prof. Dr. Ersel Onrat Afyon Kocatepe Üniversitesi Tıp Fakültesi, Türkiye
Prof. Dr. Aylin Yucel Afyon Kocatepe Üniversitesi Tıp Fakültesi, Türkiye
Prof. Dr. Faruk Ozturk Afyon Kocatepe Üniversitesi Tıp Fakültesi, Türkiye
Ali Asagidag Afyon Kocatepe Üniversitesi Tıp Fakültesi, Türkiye
Prof. Dr. Ataç ÇELİK Afyon Kocatepe Üniversitesi Tıp Fakültesi, Türkiye
Makale Türü Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
Dergi Adı Journal of Ocular Pharmacology and Therapeutics (Q4)
Dergi ISSN 1080-7683 Wos Dergi Scopus Dergi
Dergi Tarandığı Indeksler SCI-Expanded
Makale Dili İngilizce Basım Tarihi 01-2004
Cilt / Sayı / Sayfa 20 / 4 / 293–310 DOI 10.1089/1080768041725344
Makale Linki https://journals.sagepub.com/doi/full/10.1089/1080768041725344
UAK Araştırma Alanları
Göz Hastalıkları
Özet
Objective: This study evaluated systemic and ocular acute safety and intraocular pressure (IOP)-lowering efficacy of travoprost 0.004% and bimatoprost 0.03%, compared to brimonidine 0.2% and betaxolol 0.25% in healthy subjects. Patients and Method: Nineteen (19) young men, ages between 24 and 42, were enrolled in a single-center, institutional randomized, double-masked, crossover clinical trial. Baseline IOP, heart rate, blood pressure, and respiratory rate were recorded at hour 0. At minute 30, heart rate, blood pressure, respiratory rate, and spirometry were measured. At hour 1, color Doppler imaging of retrobulbar vessels was performed. At hour 2, heart rate, blood pressure, and respiratory rate were measured; spirometry and a 15-minute treadmill test were performed. The same protocol was applied after one drop of a study medication was instilled into each eye on four subsequent visits at 5-day …
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