Bioassay-guided isolation and identification of antioxidant flavonoids from Cyclotrichium origanifolium (Labill.) manden and scheng
Yazarlar (4)
Abdussamat Güzel Harran Üniversitesi, Türkiye
Hüseyin Akşit Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Mahfuz Elmastaş Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Prof. Dr. Ramazan ERENLER Tokat Gaziosmanpaşa Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | PHARMACOGNOSY MAGAZINE (Q4) | ||
| Dergi ISSN | 0973-1296 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 04-2017 |
| Cilt / Sayı / Sayfa | 13 / 50 / 316–320 | DOI | 10.4103/0973-1296.204556 |
| Makale Linki | http://www.phcog.com/text.asp?2017/13/50/316/204556 | ||
| Özet |
| Medicinal and aromatic plants play a significant role in drug discovery and development process. Flavonoids, revealing a wide spectrum of biological activities, extensively found in plants are important secondary metabolites. Aerial parts of were collected, dried, and boiled in water then extracted with hexane, ethyl acetate, and -butanol. Total phenolic content, DPPH scavenging activity, reducing power (FRAP) activity, and ABTS scavenging activity assays were applied for all extracts. The ethyl acetate extract revealing the most antioxidant activity as well as including the highest phenolic contents was subjected to chromatographic techniques (column chromatography, sephadex LH-20, semipreparative HPLC) to isolate the active compounds. The structure of isolated compounds were elucidated by spectroscopic methods (1D NMR, 2D NMR, and LC-TOF/MS). Isosakuranetin (1), eriodictyol (2), luteolin (3), naringenin (4), and apigenin (5) were isolated and identified. All isolated flavonoids displayed the excellent antioxidant activity. The isolated flavonoids and also plant extract have potency to be a natural antioxidant. Five flavonoids were isolated from Isolated compounds revealed the good antioxidant activity has a potency to be used in food industries DPPH•: 1,1-diphenyl-2-picryl-hydrazyl free radical, ABTS•+: 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid), UV:Ultraviolet, DNA: Deoxyribonucleic acid, BHT: Butylated hydroxytoluene, BHA: Butylated hydroxyanisole, HPLC: High performance liquid chromatography. |
| Anahtar Kelimeler |
| antioxidant activity | Cyclotrichium origanifolium | flavonoids | isolation | spectroscopy |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 40 |