Bioassay-guided isolation, identification of compounds from Origanum rotundifolium and investigation of their antiproliferative and antioxidant activities
Yazarlar (7)
Prof. Dr. Ramazan ERENLER Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Bılal Meral Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Ozkan Sen Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Mahfuz Elmastas Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Prof. Dr. Ali Aydın Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Özgür Eminağaoğlu Artvin Çoruh Üniversitesi, Türkiye
Gulactı Topcu Bezmiâlem Vakıf Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | Pharmaceutical Biology (Q2) | ||
| Dergi ISSN | 1388-0209 Dergi Bilgileri (2017) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 04-2017 |
| Kabul Tarihi | 21-03-2017 | Yayınlanma Tarihi | 01-01-2017 |
| Cilt / Sayı / Sayfa | 55 / 1 / 1646–1653 | DOI | 10.1080/13880209.2017.1310906 |
| Makale Linki | https://www.tandfonline.com/doi/pdf/10.1080/13880209.2017.1310906?needAccess=true | ||
| UAK Araştırma Alanları |
Organik Kimya
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| Özet |
| Context: Origanum (Lamiaceae) has been used in food and pharmaceutical industries.Objective: Isolation and identification of bioactive compounds from Origanum rotundifolium Boiss. and investigation of their antiproliferative and antioxidant activities.Materials and methods: The aerial part of O. rotundifolium was dried and powdered (1.0 kg ±2.0 g) then extracted with hexane, ethyl acetate, methanol and water. Solvent (3 × 1 L) was used for each extraction for a week at room temperature. The aqueous extract was partitioned with ethyl acetate (3 × 1 L) to yield the water/EtOAc extract subjected to chromatography to isolate the active compounds. The structures of isolated compounds were elucidated by 1 D, 2 D NMR and LC-TOF/MS.Results: Apigenin (1), ferulic acid (2), vitexin (3), caprolactam (4), rosmarinic acid (5), and globoidnan A (6) were isolated and identified. Globoidnan A (6), vitexin (3), and … |
| Anahtar Kelimeler |
| Chromatography | Isolation | Secondary metabolites | Spectroscopy |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Yöksis | 53 |
| Web of Science | 70 |
| Scopus | 82 |
| Google Scholar | 135 |