Isolation, Characterization, and Antiproliferative Activity of Polymethoxy Flavones from Mentha dumetorum
Yazarlar (3)
Hüseyin Akşit Erzincan Binali Yıldırım Üniversitesi, Türkiye
Erdem Ozan Iğdır Üniversitesi, Türkiye
Prof. Dr. Ramazan ERENLER Tokat Gaziosmanpaşa Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(ESCI dergilerinde yayınlanan tam makale)
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| Dergi Adı | Natural Products Journal | ||
| Dergi ISSN | 2210-3155 Dergi Bilgileri (2023) | ||
| Dergi Tarandığı Indeksler | E-SCI | ||
| Makale Dili | Türkçe | Basım Tarihi | 01-2023 |
| Kabul Tarihi | 17-10-2022 | Yayınlanma Tarihi | 01-11-2023 |
| Cilt / Sayı / Sayfa | 13 / 7 / 20–26 | DOI | 10.2174/2210315513666221125142944 |
| Makale Linki | http://dx.doi.org/10.2174/2210315513666221125142944 | ||
| UAK Araştırma Alanları |
Organik Kimya
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| Özet |
| Background Natural products have been used commonly in the pharmaceutical industry as well as traditional medicine due to their bioactive contents. Objective The objective of this study is to isolate the polymethoxy flavones (PMFs) and evaluate the antiproliferative activity. Methods The PMFs were extracted from Mentha dumetorum with boiling hot water and then partitioned with hexane and the extract was subjected to chromatographic techniques such as Sephadex LH-20, silica gel, and preparative TLC, and HPLC to isolate the compounds. The structures of isolated compounds were elucidated by spectroscopic techniques such as 1H-NMR, 13C-NMR, LC-TOF-MS, and UV-Vis. The antiproliferative effects of isolated compounds were evaluated using a real-time cell analyzer–single plate (RTCA-SP) instrument against HeLa and HT29 cell lines. Results The isolated PMFs were identified as xanthomicrol (1), 5 … |
| Anahtar Kelimeler |
| antiproliferative activity | cancer | cell lines | Mentha dumetorum | perennial plant | polymethoxylated flavones |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 1 |
| Scopus | 3 |
| Google Scholar | 4 |