Phytochemical Profile, Anti-lipid peroxidation and Anti-diabetic activities of Thymus algeriensis Boiss. & Reut
Yazarlar (7)
Zaoui Heyem Université Constantine 1, Cezayir
Boutaoui Nassima Université Constantine 1, Cezayir
Menad Ahmed Université Constantine 1, Cezayir
Prof. Dr. Ramazan ERENLER Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Zaiter Lahcene Université Constantine 1, Cezayir
Benayache Fadila Université Constantine 1, Cezayir
Ameddah Souad Université Constantine 1, Cezayir
| Makale Türü | Özgün Makale (ESCI dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Egyptian Journal of Chemistry | ||
| Dergi ISSN | 0449-2285 Dergi Bilgileri (2022) | ||
| Dergi Tarandığı Indeksler | Emerging Sources Citation Index | ||
| Makale Dili | İngilizce | Basım Tarihi | 12-2022 |
| Kabul Tarihi | – | Yayınlanma Tarihi | 21-04-2022 |
| Cilt / Sayı / Sayfa | 65 / 12 / 695–705 | DOI | 10.21608/EJCHEM.2022.126336.5600 |
| Makale Linki | http://dx.doi.org/10.21608/ejchem.2022.126336.5600 | ||
| UAK Araştırma Alanları |
Organik Kimya
Spektroskopi
Nanoteknoloji
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| Özet |
| Thymus algeriens Bioss & Reut is an Algerian native plant traditionally used for culinary and medicinal purposes. Biological activities varied with their chemical composition, which depends on the floral and geographical origin. This study was designed to screen the phenolic content of the n-BuOH extract of Thymus algeriensis (BETA), anti-lipid peroxidation and anti-diabetic properties on different in vitro models. The results showed, that BETA reduced TBARS formation in a concentration-dependent manner; protected β-carotene from auto-oxidation and prevented oxidation of ferrous in the linoleic acid/ferric thiocyanate assay. Furthermore, BETA showed effective inhibitions of the key enzymes linked to type 2 diabetes; 𝛼-amylase and 𝛼-glucosidase. BETA blocked also the formation of AGE as shown by the results of glucose-BSA (BSA-GLU), BSA-Methylglyoxal system (BSA-MGO) and glycated hemoglobin. The effectiveness of BETA in combating diabetics might be influenced by the synergistic action of its phenolic compounds; mentioned by the phenolic content and LC/MS analysis; particularly their richness on the rosmarinic acid and ferulic acid, cafeic acid as well quercetin. This suggests the potential of BETA to mitigate multiple complications stemming from oxidative stress and protein glycation in diabetes. |
| Anahtar Kelimeler |
| Anti-glycation | Anti-lipid peroxidation | LC-MS | Thymus algeriensis | α-amylase | α-glucosidase |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 4 |
| Scopus | 5 |
| Google Scholar | 8 |