Phenolic Profile, Acute Toxicity, and Hepatoprotective and Antiproliferative Activities of Algerian Ruta tuberculata Forssk
Yazarlar (5)
Asma Saidi Université Batna 2, Cezayir
Leila Hambaba Université Batna 2, Cezayir
Burak Kucuk Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Prof. Dr. Ercan ÇAÇAN Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Prof. Dr. Ramazan ERENLER Tokat Gaziosmanpaşa Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SCOPUS dergilerinde yayınlanan tam makale)
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| Dergi Adı | Current Bioactive Compounds | ||
| Dergi ISSN | 1573-4072 Dergi Bilgileri (2022) | ||
| Dergi Tarandığı Indeksler | Scopus | ||
| Makale Dili | İngilizce | Basım Tarihi | 02-2022 |
| Kabul Tarihi | 21-10-2021 | Yayınlanma Tarihi | 01-03-2022 |
| Cilt / Sayı / Sayfa | 18 / 3 / 72–83 | DOI | 10.2174/1573407217666211119092552 |
| Makale Linki | http://dx.doi.org/10.2174/1573407217666211119092552 | ||
| UAK Araştırma Alanları |
Organik Kimya
Spektroskopi
Nanoteknoloji
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| Özet |
| Objectives Ruta tuberculata forssk. (Rutaceae) is an aromatic plant widely used in traditional Algerian medicine due to its pharmaceutical virtues against various disorders. This study aims to determine the phenolic profile of aqueous (RAE) and methanol (RME) extracts of R. tuberculata aerial parts and to investigate their acute oral toxicity, as well as their possible antiproliferative and hepatoprotective effects. Methods Polyphenols were identified by quantitative LC-MS/MS analysis. Oral acute toxicity was performed according to OCDE guidelines. The hepatoprotective activity was evaluated by paracetamol-induced hepatotoxicity and supported by biochemical and histological analysis of liver and kidneys. The antiproliferative activity against human colorectal HT-29 and ovarian OV2008 cancer cell lines was determined using SRB assay. Results LC-MS/MS analysis revealed that RME has higher phenols and … |
| Anahtar Kelimeler |
| acute oral toxicity | antiproliferative activity | flavonoids | hepatoprotective activity | LC-MS/MS anal-ysis | R. tuberculata |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Scopus | 12 |
| Google Scholar | 19 |