The preventive effects of Centaurea maroccana Ball. extract against oxidative stress induced by cisplatin in mice brains: in vitro and in vivo studies
Yazarlar (7)
Imane Aissous Université Constantine 1, Cezayir
Mouad Benrebai Université Constantine 1, Cezayir
Souad Ameddah Université Constantine 1, Cezayir
Ahmed Menad Université Constantine 1, Cezayir
Prof. Dr. Ramazan ERENLER Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Samir Benayache Université Constantine 1, Cezayir
Fadila Benayache Université Constantine 1, Cezayir
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Drug and Chemical Toxicology (Q2) | ||
| Dergi ISSN | 0148-0545 Dergi Bilgileri (2023) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 11-2023 |
| Kabul Tarihi | 15-10-2022 | Yayınlanma Tarihi | 04-11-2022 |
| Cilt / Sayı / Sayfa | 46 / 6 / 1162–1175 | DOI | 10.1080/01480545.2022.2139841 |
| Makale Linki | http://dx.doi.org/10.1080/01480545.2022.2139841 | ||
| UAK Araştırma Alanları |
Organik Kimya
Spektroskopi
Nanoteknoloji
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| Özet |
| Since antiquity, Centaurea species have been used in folk medicine to treat several diseases owing to their potential biological activities that distinguish this genus such as antioxidant, anticancer, and anti-inflammatory effect. The current study aimed to investigate the possible neuroprotective effects of the n-butanol extract of Centaurea maroccana (BECM) against cisplatin (CP) induced neurotoxicity in mice. BECM’s potential neuroprotective properties were studied in vitro and in vivo models. Male Swiss albino mice were orally received BECM (200 mg/kg) for 10 days before a single intraperitoneal injection of cisplatin (8 mg/kg). Vitamin E (100 mg/kg) was given daily by gavage as a positive control. In vitro results revealed that BECM inhibited lipid peroxidation (LPO) levels and acetylcholinesterase (AChE) activity. In vivo findings showed that BECM pretreatment was able to regulate lactate dehydrogenase … |
| Anahtar Kelimeler |
| Centaurea maroccanaBall | Cisplatin | LC-MS/MS analysis | neurotoxicity | oxidative stress | vitamin E |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 7 |
| Scopus | 7 |
| Google Scholar | 14 |