Antiproliferative and cytotoxic effects of bioactive compounds isolated from Onosma bourgaei
Yazarlar (4)
Prof. Dr. Ramazan ERENLER Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Doç. Dr. İlyas YILDIZ Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Ali Aydın Yozgat Bozok University, Türkiye
Doç. Dr. Nusret GENÇ Tokat Gaziosmanpaşa Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | Medical Oncology (Q3) | ||
| Dergi ISSN | 1357-0560 Dergi Bilgileri (2022) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 06-2022 |
| Kabul Tarihi | 08-03-2022 | Yayınlanma Tarihi | 08-06-2022 |
| Cilt / Sayı / Sayfa | 39 / 8 / 116–0 | DOI | 10.1007/s12032-022-01705-z |
| Makale Linki | http://dx.doi.org/10.1007/s12032-022-01705-z | ||
| UAK Araştırma Alanları |
Organik Kimya
Spektroskopi
Nanoteknoloji
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| Özet |
| Onosma species have been used commonly for traditional medicine for years due to their bioactive compounds content. Onosma bourgaei aerial part was extracted with hexane and methanol successively. The methanol extract was subjected to chromatographic techniques to isolate allantoin (1), 3,4-dihydroxybenzaldehyde (2), luteolin-7-O-glucoside (3), apigenin-7-O-β-glucoside (4), diosmetin-7-O-β-glucoside (5), rosmarinic acid (6), and globoidnan A (7). The structure of isolated compounds were identified by spectroscopic techniques such as 1D-NMR, 2D-NMR, FTIR, and LC-TOF/MS/MS. Antiproliferative activity of extract and natural compounds were carried out using HeLa (human epithelial cervix adenocarcinoma, ATCC® CCL-2™), HT29 (human colorectal adenocarcinoma, ATCC® HTB38™), MCF7 (human mammary gland adenocarcinoma, ATCC® HTB22™), and A549 (human lung carcinoma, ATCC® … |
| Anahtar Kelimeler |
| Antiproliferative activity | Cancer cell lines | Chromatography | Onosma bourgaei | Spectroscopy |
