Fatty acid constituents and anticancer activity of Cladophora fracta (OF Müller ex Vahl) Kützing
Yazarlar (2)
Tünay Karan Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Prof. Dr. Ramazan ERENLER Tokat Gaziosmanpaşa Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | Tropical Journal of Pharmaceutical Research (Q4) | ||
| Dergi ISSN | 1596-5996 Dergi Bilgileri (2018) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 10-2018 |
| Kabul Tarihi | – | Yayınlanma Tarihi | 18-03-2019 |
| Cilt / Sayı / Sayfa | 17 / 10 / 1977–1982 | DOI | 10.4314/tjpr.v17i10.12 |
| Makale Linki | http://www.tjpr.org | ||
| UAK Araştırma Alanları |
Organik Kimya
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| Özet |
| Methods: Cladophora fracta (OF Müller ex Vahl) Kützing was collected from natural ponds in Tokat, Turkey. Antiproliferative and cytotoxic effects of methanol and hexane extracts of C. fracta were investigated on human colon carcinoma (HT29) and non-tumorigenic African green monkey kidney (Vero) cell lines using BrdU cell proliferation enzyme-linked Immunosorbent assay (ELISA) and lactate dehydrogenase (LDH) test, respectively. The fatty acid composition of hexane extract was analyzed by gas chromatography-mass spectrometry (GC-MS).Results: Oleic acid, palmitic acid, gamma-linoleic acid and linoleic acid were the main constituents of C. fracta. The methanol extract exhibited strong antiproliferative activity on HT29 and Vero cell lines (p< 0.05). The hexane extract revealed its good antiproliferative activity at high concentrations on both cell lines. Cytotoxicity results showed that both methanol and hexane extract had low effect on HT29 cell at low concentrations.Conclusion: Due to the strong antiproliferative effect of C. fracta methanol extract on HT29 and Vero cell lines, it has potential anticancer properties and recommended for further development as such. |
| Anahtar Kelimeler |
| Anti-cancer | Antiproliferative activity | Cladophora fracta | Cytotoxic effect | Fatty acid |
BM Sürdürülebilir Kalkınma Amaçları
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| Yöksis | 9 |
| Web of Science | 29 |
| Scopus | 34 |
| Google Scholar | 51 |