Preparation of new mono- and bis-amide derivatives of L-isoleucine via amidation of carboxyl and amino groups
Yazarlar (5)
Murat Sunkur Batman Üniversitesi, Türkiye
Sara Aydın Batman Üniversitesi, Türkiye
Prof. Dr. Tarık Aral Batman Üniversitesi, Türkiye
Doç. Dr. Beşir Dağ Batman Üniversitesi, Türkiye
Prof. Dr. Ramazan ERENLER Tokat Gaziosmanpaşa Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(ESCI dergilerinde yayınlanan tam makale)
|
||
| Dergi Adı | Organic Communications | ||
| Dergi ISSN | 1307-6175 Dergi Bilgileri (2021) | ||
| Dergi Tarandığı Indeksler | TR DİZİN | ||
| Makale Dili | İngilizce | Basım Tarihi | 07-2021 |
| Kabul Tarihi | – | Yayınlanma Tarihi | 19-09-2021 |
| Cilt / Sayı / Sayfa | 14 / 3 / 294–299 | DOI | 10.25135/acg.oc.112.21.07.2139 |
| Makale Linki | http://dx.doi.org/10.25135/acg.oc.112.21.07.2139 | ||
| UAK Araştırma Alanları |
Organik Kimya
|
||
| Özet |
| N, N′-Dicyclohexylcarbodiimide and hydroxybenzotriazole mediated amination of free COOH group of N-tert-butyloxyoxycarbonyl-L-isoleucine 1 with three aromatic amines gave the corresponding amides 2a-c. Deprotection of N-tert-butyloxyoxycarbonyl groups of 2a-c with AcOH yielded the related amine derivatives 3a-c. The amidation of the free NH2 groups of (3a-c) with phthaloyl dichloride yielded the bis-amide products 4a-c. The synthesized compounds were purified by crystallization and their structures were elucidated by spectroscopic methods such as 1H-HMR, 13C-NMR, FTIR, and micro analysis. |
| Anahtar Kelimeler |
| Amides | coupling reaction | heterocyclic | N-boc-deprotection | spectroscopy | tetraamides |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 3 |
| Scopus | 4 |
| Google Scholar | 7 |
| TR Dizin | 2 |