Syntheses neural protective activities and inhibition of glycogen synthase kinase 3 of substituted quinolines
Yazarlar (24)
Jianyu Lu Kansas State University, Amerika Birleşik Devletleri
Jianyu Lu Kansas State University, Amerika Birleşik Devletleri
Izumi Maezawa Uc Davis Mınd Institute, Amerika Birleşik Devletleri
Izumi Maezawa Uc Davis Mınd Institute, Amerika Birleşik Devletleri
Sahani Weerasekara Kansas State University, Amerika Birleşik Devletleri
Sahani Weerasekara Kansas State University, Amerika Birleşik Devletleri
Prof. Dr. Ramazan ERENLER Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Prof. Dr. Ramazan ERENLER Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Tuyen D.T. Nguyen Kansas State University, Amerika Birleşik Devletleri
Tuyen D.T. Nguyen Kansas State University, Amerika Birleşik Devletleri
James Nguyen Kansas State University, Amerika Birleşik Devletleri
James Nguyen Kansas State University, Amerika Birleşik Devletleri
Luxi Z. Swisher Kansas State University, Amerika Birleşik Devletleri
Luxi Z. Swisher Kansas State University, Amerika Birleşik Devletleri
Jun Li Kansas State University, Amerika Birleşik Devletleri
Jun Li Kansas State University, Amerika Birleşik Devletleri
Lee Way Jin Uc Davis Mınd Institute, Amerika Birleşik Devletleri
Lee Way Jin Uc Davis Mınd Institute, Amerika Birleşik Devletleri
Alok Ranjan
Texas Tech University Health Sciences Center At Amarillo, Amerika Birleşik Devletleri
Texas Tech University Health Sciences Center At Amarillo, Amerika Birleşik Devletleri
Alok Ranjan
Texas Tech University Health Sciences Center At Amarillo, Amerika Birleşik Devletleri
Texas Tech University Health Sciences Center At Amarillo, Amerika Birleşik Devletleri
Sanjay K. Srivastava Texas Tech University Health Sciences Center At Amarillo, Amerika Birleşik Devletleri
Sanjay K. Srivastava Texas Tech University Health Sciences Center At Amarillo, Amerika Birleşik Devletleri
Duy H. Hua Kansas State University, Amerika Birleşik Devletleri
Duy H. Hua Kansas State University, Amerika Birleşik Devletleri
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | Bioorganic and Medicinal Chemistry Letters (Q2) | ||
| Dergi ISSN | 0960-894X Dergi Bilgileri (2014) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 08-2014 |
| Kabul Tarihi | – | Yayınlanma Tarihi | 01-08-2014 |
| Cilt / Sayı / Sayfa | 24 / 15 / 3392–3397 | DOI | 10.1016/j.bmcl.2014.05.085 |
| Makale Linki | http://linkinghub.elsevier.com/retrieve/pii/S0960894X14005940 | ||
| UAK Araştırma Alanları |
Organik Kimya
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| Özet |
| A new series of fifteen 5-, 6-, and 8-appended 4-methylquinolines were synthesized and evaluated for their neural protective activities. Selected compounds were further examined for their inhibition of glycogen synthase kinase-3β (GSK-3β) and protein kinase C (PKC). Two most potent analogs, compounds 3 and 10, show nanomolar protective activities in amyloid β-induced MC65 cells and enzymatic inhibitory activities against GSK-3β, but poor PKC inhibitory activities. Using normal mouse model, the distribution of the most potent analog 3 in various tissues and possible toxic effects in the locomotors and inhibition of liver transaminases activities were carried out. No apparent decline of locomotor activity and no inhibition of liver transaminases were found. The compound appears to be safe for long-term use in Alzheimer’s disease mouse model. |
| Anahtar Kelimeler |
| Alzheimer's disease | Amyloid β | Glycogen synthase kinase-3β | Neural protective activity | Protein kinase C | Quinolines |
Science Direct
Syntheses neural protective activities and inhibition of glycogen synthase kinase 3 of substituted quinolines
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Yöksis | 8 |
| Web of Science | 15 |
| Scopus | 18 |
| Google Scholar | 28 |