Inhibitory Effect of 6,7-dimethoxy-5-hydroxyflavone on Human Cervix Carcinoma in Vitro
Yazarlar (5)
Prof. Dr. Ramazan ERENLER Tokat Gaziosmanpaşa Üniversitesi, Türkiye
İbrahim Demirtaş Çankırı Karatekin Üniversitesi, Türkiye
Tünay Karan Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Muhammed Altun Çankırı Karatekin Üniversitesi, Türkiye
Fatih Gül Çankırı Karatekin Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(Ulusal alan endekslerinde (TR Dizin, ULAKBİM) yayınlanan tam makale)
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| Dergi Adı | International Journal of Secondary Metabolite | ||
| Dergi ISSN | 2148-6905 Scopus Dergi | ||
| Dergi Tarandığı Indeksler | TR DİZİN | ||
| Makale Dili | İngilizce | Basım Tarihi | 11-2017 |
| Cilt / Sayı / Sayfa | 4 / 3 / 512–516 | DOI | – |
| Özet |
| Natural products derived from plants play a significant role in drug discovery due to the revealing a large variety of pharmaceutical effects. Kickxia spuriawas collected from Bingol, Turkey. Aerial parts of the plant were boiled in water for 2 h then extracted with ethyl acetate. After evaporation of the solvent by rotary evaporator, the extract was subjected to column chromatography to yield the compound identified as 6,7-dimethoxy-5hydroxyflavone by spectroscopic method including 1D-, 2D-NMR, LC-TOF/MS. Antiproliferative activity of isolated compound was tested against HeLa (human cervix carcinoma) cell lines by xCELLigence assay, and found out that the compound exhibited excellent activity. |
| Anahtar Kelimeler |
