Activation of peripheral opioid receptors has no effect on heart rate variability
Yazarlar (6)
Ender Ellidokuz
Manisa Celâl Bayar Üniversitesi, Türkiye
Manisa Celâl Bayar Üniversitesi, Türkiye
Dayimi Kaya
Sb Tepecik Research And Training Hospital, Izmir, Türkiye
Sb Tepecik Research And Training Hospital, Izmir, Türkiye
Ihsan Uslan
Afyon Kocatepe Üniversitesi, Türkiye
Afyon Kocatepe Üniversitesi, Türkiye
Prof. Dr. Ataç ÇELİK Afyon Kocatepe Üniversitesi, Türkiye
Ali Metin Esen
Kosuyolu Heart Education And Research Hospital, Türkiye
Kosuyolu Heart Education And Research Hospital, Türkiye
Irfan Barutca
Kosuyolu Heart Education And Research Hospital, Türkiye
Kosuyolu Heart Education And Research Hospital, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Clinical Autonomic Research (Q4) | ||
| Dergi ISSN | 0959-9851 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2008 |
| Cilt / Sayı / Sayfa | 18 / 3 / 145–149 | DOI | 10.1007/s10286-008-0469-9 |
| Makale Linki | http://link.springer.com/10.1007/s10286-008-0469-9 | ||
| UAK Araştırma Alanları |
Kardiyoloji
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| Özet |
| Opioid receptors involved in regulating the motility of the gastrointestinal tract have been localized in both contractile and neuronal tissues. Trimebutine, a peripheral opioid receptor agonist, modulates gastrointestinal motor activity in both directions and also may act on cardiac tissue. This study investigated the effects of trimebutine in clinical doses on cardiac autonomic functions with heart rate variability. The effect of trimebutine on cardiac autonomic outflows was evaluated in 11 healthy subjects. Trimebutine (200 mg) or placebo was administered orally at random in a double-blind, cross-over manner. Continuous electrocardiography recordings were obtained before and after drug administration during three states: rest, controlled breathing, and a hand grip exercise. Heart rate variability analysis showed that there was no significant difference between subjects administered with placebo or trimebutine throughout … |
| Anahtar Kelimeler |
| Autonomic nervous system | Heart | HRV | Opioid receptor | Trimebutine |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 2 |
| Scopus | 2 |
| Google Scholar | 6 |