Activation of peripheral opioid receptors has no effect on heart rate variability
Yazarlar (6)
Manisa Celâl Bayar Üniversitesi, Türkiye
Sb Tepecik Research And Training Hospital, Izmir, Türkiye
Afyon Kocatepe Üniversitesi, Türkiye
Kosuyolu Heart Education And Research Hospital, Türkiye
Kosuyolu Heart Education And Research Hospital, Türkiye
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | Clinical Autonomic Research |
| Dergi ISSN | 0959-9851 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI |
| Dergi Grubu | Q4 |
| Makale Dili | İngilizce |
| Basım Tarihi | 01-2008 |
| Cilt No | 18 |
| Sayı | 3 |
| Sayfalar | 145 / 149 |
| DOI Numarası | 10.1007/s10286-008-0469-9 |
| Özet |
| Opioid receptors involved in regulating the motility of the gastrointestinal tract have been localized in both contractile and neuronal tissues. Trimebutine, a peripheral opioid receptor agonist, modulates gastrointestinal motor activity in both directions and also may act on cardiac tissue. This study investigated the effects of trimebutine in clinical doses on cardiac autonomic functions with heart rate variability. The effect of trimebutine on cardiac autonomic outflows was evaluated in 11 healthy subjects. Trimebutine (200 mg) or placebo was administered orally at random in a double-blind, cross-over manner. Continuous electrocardiography recordings were obtained before and after drug administration during three states: rest, controlled breathing, and a hand grip exercise. Heart rate variability analysis showed that there was no significant difference between subjects administered with placebo or trimebutine throughout rest, controlled breathing, or the hand grip exercise. We concluded that trimebutine, in clinical doses, has no significant effect on cardiac autonomic functions. © 2008 Springer. |
| Anahtar Kelimeler |
| Autonomic nervous system | Heart | HRV | Opioid receptor | Trimebutine |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| SCOPUS | 2 |
| Google Scholar | 7 |