Inhibition of Various Cancer Cells Proliferation of Bornyl Acetate and Essential Oil from Inula graveolens (Linnaeus) Desf.
Yazarlar (4)
Tünay Karan Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Doç. Dr. İlyas YILDIZ Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Ali Aydın Bartın Üniversitesi, Türkiye
Prof. Dr. Ramazan ERENLER Tokat Gaziosmanpaşa Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | Records of Natural Products (Q2) | ||
| Dergi ISSN | 1307-6167 Dergi Bilgileri (2018) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 05-2018 |
| Kabul Tarihi | – | Yayınlanma Tarihi | 15-01-2018 |
| Cilt / Sayı / Sayfa | 12 / 3 / 273–283 | DOI | 10.25135/rnp.30.17.09.057 |
| Makale Linki | https://doi.org/10.25135/rnp.30.17.09.057 | ||
| UAK Araştırma Alanları |
Organik Kimya
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| Özet |
| Inula species are medicinal and aromatic plants used for folk medicine extensively. In this work, hydrodistilled essential oil of Inula graveolens (Linnaeus) Desf. analyzed by GC-MS which revealed that bornyl acetate was the major product (69.15%). Camphene was the second major compound (11.11%). Antiproliferative activity of the essential oil and bornyl acetate was investigated on HeLa (human cervix carcinoma), HT29 (human colon carcinoma), A549 (human lung carcinoma), MCF7 (human breast adenocarcinoma) cancer cells and FL (human amnion cells) normal cells. The cytotoxicity was executed by a Lactate Dehydrogenase (LDH) Cytotoxicity Detection Kit. Essential oil and bornyl acetate displayed the outstanding activities on HeLa (IC50, 64.1, 72.0 mu g/mL), HT29 (IC50, 24.6, 60.5 mu g/mL), A549 (IC50, 28.3, 44.1 mu g/mL), MCF-7 (IC50, 66.5, 85.6 mu g/mL), and FL (IC50, 42.1, 50.6 mu g/mL) cell lines respectively. |
| Anahtar Kelimeler |
| Antitumor activity | Essential oil | Inula graveolens |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Yöksis | 14 |
| Web of Science | 46 |
| Scopus | 55 |
| Google Scholar | 73 |
| TR Dizin | 5 |