Bioactivity–guided isolation of flavonoids from Cynanchum acutum L. subsp. sibiricum (willd.) Rech. f. and investigation of their antiproliferative activity
Yazarlar (5)
İlyas Yildiz Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Özkan Şen Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Prof. Dr. Ramazan ERENLER Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Prof. Dr. İbrahim Demirtaş Çankırı Karatekin Üniversitesi, Türkiye
Lütfi Behçet Bingöl Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | Natural Product Research (Q2) | ||
| Dergi ISSN | 1478-6419 Dergi Bilgileri (2017) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2017 |
| Kabul Tarihi | 05-01-2017 | Yayınlanma Tarihi | 14-02-2017 |
| Cilt / Sayı / Sayfa | 31 / 22 / 2629–2633 | DOI | 10.1080/14786419.2017.1289201 |
| Makale Linki | https://www.tandfonline.com/doi/full/10.1080/14786419.2017.1289201 | ||
| UAK Araştırma Alanları |
Organik Kimya
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| Özet |
| Cynanchum acutum L. subsp. sibiricum (Willd.) Rech. f. was extracted with hexane, acetone, methanol and water individually. A sample was heated in water then extracted with ethyl acetate. Among the extracts, the ethyl acetate extract exhibited the most antiproliferative activity, so isolation of bioactive compounds was carried out from this extract. A new compound, kaempferol-3-O-β-xylopyranosyl-(1-2)-β-rhamnopyranoside (1) along with five known compounds, quercetin-3-O-β-xyloside (2), kaempferol-3-O-β-glucoside (3), quercetin-3-O-β-glucoside (4), kaempferol-3-O-β-rhamnopyranoside (5), and kaempferol-3-O-β-d-neohesperidoside (6) were isolated from ethyl acetate extract. The structures were elucidated by spectroscopic techniques, basically 1D NMR, 2D NMR and LC-TOF/MS. Antiproliferative effects of isolated compounds were determined by xCELLigence using the HeLa (human uterus carcinoma) cell … |
| Anahtar Kelimeler |
| antiproliferative activity | Cynanchum acutum subsp. sibiricum | flavonoids |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Yöksis | 12 |
| Web of Science | 29 |
| Scopus | 28 |
| Google Scholar | 42 |