Bioactivity Guided Isolation of Antiproliferative Sesquiterpene Lactones from Centaurea solstitialis L ssp solstitialis
Yazarlar (4)
Prof. Dr. Ramazan ERENLER Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Özkan Şen Gaziosmanpaşa Üniversitesi, Türkiye
Ayşe Şahin Yağlıoğlu Çankırı Karatekin Üniversitesi, Türkiye
Prof. Dr. İbrahim Demirtaş Çankırı Karatekin Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Combinatorial Chemistry and High Throughput Screening (Q3) | ||
| Dergi ISSN | 1386-2073 Dergi Bilgileri (2016) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2016 |
| Kabul Tarihi | – | Yayınlanma Tarihi | 06-01-2016 |
| Cilt / Sayı / Sayfa | 19 / 1 / 66–72 | DOI | 10.2174/1386207319666151203002117 |
| Makale Linki | http://www.eurekaselect.com/openurl/content.php?genre=article&issn=1386-2073&volume=19&issue=1&spage=66 | ||
| UAK Araştırma Alanları |
Organik Kimya
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| Özet |
| Centaurea solstitialis L. ssp. solstitialis (CSS) has been used as medicine for various diseases. In this work, root, stem and flower parts of the plant were separately extracted with methanol to execute bioassay-guided isolation. Antiproliferative activities of each extracts on C6 cells (Rat Brain tumor cells) and HeLa cells (human uterus carcinoma) were investigated in vitro. The methanol extract of stem exhibited the most antiproliferative activity therefore isolation of active compounds was carried out for stem of the plant. Methanol extract of stem was boiled at 97 °C for 2 hours in water and then hexane and ethyl acetate were extracted sequentially. Solstitialin A 1 and 15-dechloro-15-hydroxychlorojanerin 2 were isolated from ethyl acetate extract by column chromatography and identified by spectroscopic techniques. Solstitialin A 1 was isolated from CSS and 15-dechloro-15-hydroxychlorojanerin 2 was isolated from … |
| Anahtar Kelimeler |
| 15-dechloro-15-hydroxychlorojanerin | Centaurea solstitialis l. ssp. solstitialis | Solstitialin a |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Yöksis | 7 |
| Web of Science | 29 |
| Scopus | 34 |
| Google Scholar | 62 |