Relationship between L arginine asymmetric dimethylarginine homocysteine folic acid vitamin B levels and coronary artery ectasia
Yazarlar (13)
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Erciyes Üniversitesi, Türkiye
Selçuk Üniversitesi, Türkiye
Erciyes Üniversitesi, Türkiye
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Erciyes Üniversitesi, Türkiye
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Prof. Dr. Ataç ÇELİK
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Selçuk Üniversitesi, Türkiye
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Erciyes Üniversitesi, Türkiye
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | CORONARY ARTERY DISEASE |
| Dergi ISSN | 0954-6928 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI |
| Dergi Grubu | Q4 |
| Makale Dili | İngilizce |
| Basım Tarihi | 01-2010 |
| Cilt No | 21 |
| Sayı | 8 |
| Sayfalar | 445 / 449 |
| DOI Numarası | 10.1097/MCA.0b013e32833fd22b |
| Özet |
| Background: Coronary artery ectasia (CAE) is characterized by an abnormal dilatation of the coronary arteries. The ratio of L-arginine/asymmetric dimethylarginine (ADMA) and homocysteine are important factors for endothelial function. In this study, we investigate the ratio of L-arginine/ADMA, homocysteine, and folic acid/vitamin B levels in patients with Cae. Methods: Forty patients diagnosed with CAE using coronary angiography were included in the study (24 male; mean age, 56±11 years). The control group consisted of 30 patients who had normal coronary arteries as determined by coronary angiography (11 male; mean age, 54±8 years). The ratio of L-arginine/ADMA and plasma homocysteine was measured using high-performance liquid chromatography. Results: The L-arginine/ADMA ratio and L-arginine levels were significantly lower in the CAE group compared with the control group (110±27 vs. 149±77, P=0.02 and 157±32 μmol/l vs. 187±59 μmol/l, P=0.02, respectively). Plasma ADMA levels were similar in the two groups. Patients with CAE had higher plasma homocysteine levels (P=0.01). Plasma folic acid, vitamin B6, and vitamin B12 levels were similar between the two groups. Conclusion: This study shows that patients with CAE have a lower L-arginine/ADMA ratio and higher plasma homocysteine levels. These results show a potential relationship between endothelial dysfunction and CAE. © 2010 Wolters Kluwer Health | Lippincott Williams & Wilkins. |
| Anahtar Kelimeler |
| asymmetric dimethylarginine | coronary artery ectasia | endothelial dysfunction | folic acid | homocysteine | L-arginine | vitamin B12 | vitamin B6 |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| SCOPUS | 4 |
| Google Scholar | 6 |