HER-2/Neu and Hormone Receptor Analysis in Breast Carcinomas and Their Association with Clinicopathologic Parameters
Yazarlar (6)
Prof. Dr. Reşit Doğan KÖSEOĞLU
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Türkiye
| Makale Türü |
Özgün Makale
|
| Makale Alt Türü | ESCI dergilerinde yayınlanan tam makale |
| Dergi Adı | European Journal of Breast Health |
| Dergi ISSN | 2587-0831 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | Web of Science-Emerging Sources Citation Index |
| Makale Dili | İngilizce |
| Basım Tarihi | 10-2018 |
| Cilt No | 15 |
| Sayı | 1 |
| Sayfalar | 43 / 50 |
| DOI Numarası | 10.5152/ejbh.2018.4118 |
| Özet |
| Objective: Invasive breast carcinomas of no special type (IC-NST) are the heterogeneous tumours showing distinct prognostic features even inpatients with similar clinicopathological characteristics. To date, many clinicopathological data have been analyzed to make a guess about prognosisand to determine treatment modality. In this study, HER-2/neu status was analyzed by using both immunohistochemical (IHC) and fluorescence insitu hybridization (FISH) methods, and its correlations with hormone receptor status and clinicopathological parameters were investigated.Materials and Methods: The study was included 112 female patients with diagnosis of IC-NST. FISH for HER-2/neu was applied in onlyprimary tumour tissues, while IHC analyses for HER-2/neu, estrogen (ER) and progesterone receptors (PR) were applied on both primary andmetastatic lymph node foci. The results were compared with appropriate statistical methods.Results: Our rates of HER-2/neu overexpression and gene amplification in the overall study group were 22.3 and 25%, respectively. In the metastaticgroup, these rates were higher than those of the overall study group (34% and 40%, respectively). Gene amplification rate of the axilla positivegroup was 40%, while this rate in non-metastatic group was 6.7% (p=0.015). Overexpression and amplification results were compliant (χ2=77,591,p<0.001). The concordance rates in HER-2/neu negative and overexpression groups were 95.3% and 88%, respectively. Our false negativity ratewas 4.7%. While 36% of score 3+ cases were ER positive, 67.1% of HER-2/neu negative cases showed ER positivity (p=0.01). The increase of geneamplification rate in ER negative cases over 50 years age was more than two times and statistically significant (p=0.014).Conclusion: The concordance rates between the results of IHC and FISH in the HER-2 negative and the overexpression categories were compatiblewith the literature and lower than the literature, respectively. In the case of ER negativity, the patient's age over 50 years was associated with ahigher rate of gene amplification. |
| Anahtar Kelimeler |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| TRDizin | 1 |