Intraarticular Hyaluronic Acid Injection after Microfracture Technique for the Management of Full Thickness Cartilage Defects Does Not Improve the Quality of Repair Tissue
Yazarlar (6)
Taner Güneş Gaziosmanpaşa Üniversitesi, Türkiye
Bora Bostan Gaziosmanpaşa Üniversitesi, Türkiye
Mehmet Erdem Sakarya Üniversitesi, Türkiye
Prof. Dr. Reşit Doğan KÖSEOĞLU Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Prof. Dr. Murat Aşcı Gaziosmanpaşa Üniversitesi, Türkiye
Sen Cengiz
| Makale Türü |
Özgün Makale
(SCOPUS dergilerinde yayınlanan tam makale)
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| Dergi Adı | Cartilage | ||
| Dergi ISSN | 1947-6035 Dergi Bilgileri (2012) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 02-2012 |
| Kabul Tarihi | – | Yayınlanma Tarihi | 07-11-2011 |
| Cilt / Sayı / Sayfa | 3 / 1 / 20–26 | DOI | 10.1177/1947603511408882 |
| Makale Linki | http://car.sagepub.com/cgi/doi/10.1177/1947603511408882 | ||
| UAK Araştırma Alanları |
Ortopedi ve Travmatoloji
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| Özet |
| Objective: Tissue repair that occurs after microfracture does not include hyaline-like cartilage. Therefore, other treatment modalities must be combined with microfracture to improve repair tissue quality. In this study, we combined exogenous hyaluronic acid with microfracture. Design: Thirty mature New Zealand rabbits were randomly divided into 3 groups as control, microfracture (MF), and microfracture and hyaluronic acid (MFHA). Four-millimetre full-thickness cartilage defects were created in the medial femoral condyle of each rabbit. Microfracture was performed on defects in the MF and MFHA groups. At 1 week following surgery, 1 mL of saline was injected into the knees of the control and MF groups, whereas 1 mL (15 mg/mL) hyaluronic acid was injected into the knees of the MFHA group 3 times weekly. At 6 months postsurgery, defects were evaluated according to the ICRS (International Cartilage Repair Society) and Wakitani scales. Results: According to the ICRS and Wakitani scales, the quality of repair tissue was improved in MF and MFHA groups as compared the control group ( P = 0.001 and 0.001, respectively). No significant difference was observed between the MF and MFHA groups ( P = 0.342). Conclusions: According to the model in this study, no beneficial effect was obtained when HA injection was combined with microfracture in the treatment of full-thickness cartilage defects. |
| Anahtar Kelimeler |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Yöksis | 5 |