Syntheses of tetrachloro and tetraamino(2-furanylmethyl)spiro(N/N) cyclotriphosphazenes: Chemical, structural elucidation, antiproliferative and antimigratory activity studies
Yazarlar (7)
Doç. Dr. Hüseyin AKBAŞ
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Doç. Dr. Ayşegül ŞENOCAK
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Ankara Üniversitesi, Türkiye
Doç. Dr. Seçil ERDEN TAYHAN
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Doç. Dr. Sema BİLGİN
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Hacettepe Üniversitesi, Türkiye
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | Journal of Molecular Structure |
| Dergi ISSN | 0022-2860 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q2 |
| Makale Dili | İngilizce |
| Basım Tarihi | 06-2023 |
| Cilt No | 1282 |
| Sayı | 1 |
| DOI Numarası | 10.1016/j.molstruc.2023.135209 |
| Makale Linki | http://dx.doi.org/10.1016/j.molstruc.2023.135209 |
| Özet |
| In this research, the Schiff bases prepared from the condensation reactions of furfural with N-ethyl-1,2-diaminoethane and N-methyl-1,3-diaminopropane were reduced to N/N-donor type diamines (1 and 2) to obtain the starting diamines. The tetrachloro(2-furanylmethyl)spiro-(N/N)cyclotriphosphazenes (3 and 4) were formed regioselectively in excellent yields, when the hexachlorocyclotriphosphazene, N3P3Cl6 (HCCP, trimer), was reacted with the diamines. The Cl replacement reactions of 3 and 4 with pyrrolidine and piperidine yielded tetrapyrrolidino (3a and 4a) and tetrapiperidino (3b and 4b) cyclotriphosphazenes, respectively. The structures of all cyclotriphosphazenes were proven by FT-IR, HRMS, 1H, 13C, and 31P NMR data. The crystal structures of 3, 4, 3a, 3b and 4b were elucidated using single crystal X-ray crystallography. Tetraamino(2-furanylmethyl)spiro(N/N)cyclotriphosphazenes (3a, 3b, 4a and 4b) were tested by MTT assay for their ability to inhibit the growth of human breast cancer MCF-7, prostate cancer PC-3 and colon cancer HT-29 cells. Besides, the antimigratory activities of these compounds on three cell lines were also investigated by in vitro scratch analysis. The results show that the compounds have varying degrees of success in inhibiting the growth and migration of various cancer cells. However, the most effective phosphazene derivatives against these cancer cell lines were the five-membered N-ethyl phosphazenes (3a and 3b). |
| Anahtar Kelimeler |
| Cyclotriphosphazenes | Spectroscopy | Furan | Antiproliferative activity | Antimigratory acitivity |
Science Direct
Syntheses of tetrachloro and tetraamino(2-furanylmethyl)spiro(N/N) cyclotriphosphazenes: Chemical, structural elucidation, antiproliferative and antimigratory activity studies
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| WoS | 14 |
| SCOPUS | 16 |
| Google Scholar | 17 |