Melatonin Attenuates Cerebral Ischemia/Reperfusion Injury through Inducing Autophagy
Yazarlar (6)
Ümit Yılmaz
Arş. Gör. Kevser Tanbek Türkiye
Dr. Öğr. Üyesi Semir GÜL Malatya Turgut Özal Üniversitesi, Türkiye
Prof. Dr. Mehmet Gül İnönü Üniversitesi, Türkiye
Ahmet Koç Türkiye
Süleyman Sandal Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Neuroendocrinology Research Article (Q2) | ||
| Dergi ISSN | 0028-3835 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 06-2023 |
| Cilt / Sayı / Sayfa | 113 / 10 / – | DOI | 10.1159/000531567 |
| Makale Linki | http://dx.doi.org/10.1159/000531567 | ||
| UAK Araştırma Alanları |
Histoloji ve Embriyoloji
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| Özet |
| Introduction The aim of this study was to investigate how melatonin administration for 3 days or 7 days following cerebral ischemia (CI) injury would affect autophagy and, therefore, survival in neurons of the penumbra region. Moreover, it was also aimed at determining how this melatonin treatment would affect the neurological deficit score and rotarod and adhesive removal test durations. Methods Focal CI (90 min) was achieved in a total of 105 rats utilizing a middle cerebral artery occlusion model. After the start of reperfusion, the groups were treated with melatonin (10 mg/kg/day) for 3 days or 7 days. In all groups, neurological deficit scoring, rotarod, and adhesive removal tests were executed during reperfusion. Infarct areas were determined by TTC (2, 3, 5-triphenyltetrazolium chloride) staining at the end of the 3rd and 7th days of reperfusion. Beclin-1, LC3, p62, and caspase-3 protein levels were assessed using … |
| Anahtar Kelimeler |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Google Scholar | 27 |