Acrylamide, Applied During Pregnancy and Postpartum Period in Offspring Rats, Significantly Disrupted Myelination by Decreasing the Levels of Myelin-Related Proteins: MBP, MAG, and MOG
Yazarlar (7)
Arş. Gör. Muhammed Mehdi Üremiş Kahramanmaraş Sütçü İmam Üniversitesi, Türkiye
Arş. Gör. Nuray Üremiş Kahramanmaraş Sütçü İmam Üniversitesi, Türkiye
Prof. Dr. Mehmet Gül İnönü Üniversitesi, Türkiye
Dr. Öğr. Üyesi Semir GÜL Malatya Turgut Özal Üniversitesi, Türkiye
Prof. Dr. Yılmaz Çiğremiş Türkiye
Merve Durhan
Prof. Dr. Yusuf Türköz Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Springer Science and Business Media LLC (Q2) | ||
| Dergi ISSN | 0364-3190 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | Türkçe | Basım Tarihi | 11-2023 |
| Cilt / Sayı / Sayfa | – / 3 / – | DOI | 10.1007/s11064-023-04053-0 |
| Makale Linki | http://dx.doi.org/10.1007/s11064-023-04053-0 | ||
| UAK Araştırma Alanları |
Histoloji ve Embriyoloji
|
||
| Özet |
| Acrylamide (ACR) is a colorless, odorless, and water-soluble solid molecule. In addition to being an important industrial material, ACR is found in fried and baked carbohydrate-rich foods. ACR is regarded as a typical axonal neurotoxin that induces neuropathy. The brain is protected from oxidative damage by vitamin E, which is regarded as the most powerful fat-soluble antioxidant vitamin. This study aimed to reveal the toxic effect of ACR on the development of myelin in the brain at the molecular level and to examine whether Vitamin E has a neuroprotective effect on the harmful effect of ACR. The study was started by dividing 40 pregnant rats into 4 groups and after lactation, the study was continued with offspring rats (females and males offspring rats) from each group. Offspring rats were equally divided into Control, Vitamin E, ACR, ACR + Vitamin E groups. Following the ACR administration, the Water Maze test … |
| Anahtar Kelimeler |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Google Scholar | 12 |