Protective effects of melatonin and vitamin E in acetamiprid-induced nephrotoxicity
Yazarlar (6)
Prof. Dr. Mehmet Erman Erdemli İnönü Üniversitesi, Türkiye
Emrah Zayman
Zeynep Erdemli
Prof. Dr. Mehmet Gül İnönü Üniversitesi, Türkiye
Dr. Öğr. Üyesi Semir GÜL İnönü Üniversitesi, Türkiye
Prof. Dr. Harika Gözde Gözükara Bağ İnönü Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH (Q4) | ||
| Dergi ISSN | 0944-1344 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI | ||
| Makale Dili | İngilizce | Basım Tarihi | 03-2020 |
| Cilt / Sayı / Sayfa | 27 / 9 / 9202–9213 | DOI | 10.1007/s11356-019-06754-y |
| Makale Linki | http://link.springer.com/10.1007/s11356-019-06754-y | ||
| UAK Araştırma Alanları |
Tıbbi Biyokimya
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| Özet |
| Investigation of probable toxic effects of acetamiprid (ACMP) on kidney and comparative analysis of the probable protective effects of vitamin E and melatonin were conducted in the present study. The ethics committee approval was obtained from Inonu University Medical Faculty Ethics Committee. Fifty Balb-c mice were randomly assigned to control, corn oil, ethyl alcohol, ACMP, ACMP + melatonin, ACMP + vitamin E, and ACMP + melatonin + vitamin E groups. At the end of the experiments, rat kidney tissues were incised under anesthesia. Blood samples and kidney tissues were examined. After 21 days of ACMP administration, it was observed that malondialdehyde (MDA), total oxidant status (TOS), BUN, creatinine, IL-6, IL-1β, and TNF-α levels, histopathological damage, and Caspase-3 immunoreactivity scores increased, and glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), and total antioxidant … |
| Anahtar Kelimeler |
| Acetamiprid | Melatonin | Vitamin E | Oxidative stress | Nephrotoxicity |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 37 |
| Google Scholar | 51 |