Neuroprotection against CCl induced brain damage with crocin in Wistar rats
Yazarlar (8)
Eyüp Altınöz Karabük Üniversitesi, Türkiye
Prof. Dr. Mehmet Erman Erdemli Niğde Ömer Halisdemir Üniversitesi, Türkiye
Prof. Dr. Mehmet Gül İnönü Üniversitesi, Türkiye
Zeynep Aksungur
Türkiye
Türkiye
Dr. Öğr. Üyesi Semir GÜL İnönü Üniversitesi, Türkiye
Prof. Dr. Harika Gözde Gözükara Bağ İnönü Üniversitesi, Türkiye
Gül Büşra Kaya
Prof. Dr. Yusuf Türköz İnönü Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Biotechnic Histochemistry (Q2) | ||
| Dergi ISSN | 1052-0295 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI | ||
| Makale Dili | İngilizce | Basım Tarihi | 09-2018 |
| Cilt / Sayı / Sayfa | 93 / 8 / 623–631 | DOI | 10.1080/10520295.2018.1519725 |
| Makale Linki | https://www.tandfonline.com/doi/full/10.1080/10520295.2018.1519725 | ||
| UAK Araştırma Alanları |
Tıbbi Biyokimya
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| Özet |
| Owing to its lipophilic property, carbon tetrachloride (CCl4) is rapidly absorbed by both the liver and brain. We investigated the protective effects of crocin against brain damage caused by CCl4. Fifty rats were divided into five groups of ten: control, corn oil, crocin, CCl4 and CCl4 + crocin. CCl4 administration decreased glutathione (GSH) and total antioxidant status (TAS) levels, and catalase (CAT) activity, while significant increases were observed in malondialdehyde (MDA) and total oxidant status (TOS) levels and superoxide dismutase (SOD) activity. The cerebral cortex nuclear lamina developed a spongy appearance, neuronal degeneration was observed in the hippocampus, and heterochromatic and pyknotic neurons with increased cytoplasmic eosinophilia were observed in the hippocampus after CCl4 treatment. Because crocin exhibits strong antioxidant properties, crocin treatment increased GSH and TAS … |
| Anahtar Kelimeler |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 20 |
| Google Scholar | 32 |