Ameliorative effects of crocin on the inflammation and oxidative stress-induced kidney damage by experimental periodontitis in rats
Yazarlar (8)
İnönü Üniversitesi, Türkiye
Türkiye
İnönü Üniversitesi, Türkiye
Karabük Üniversitesi, Türkiye
Karabük Üniversitesi, Türkiye
İnönü Üniversitesi, Türkiye
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | Iranian Journal of Basic Medical Sciences |
| Dergi ISSN | 2008-3866 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q3 |
| Makale Dili | İngilizce |
| Basım Tarihi | 06-2021 |
| Cilt No | 24 |
| Sayı | 6 |
| Sayfalar | 823 / 832 |
| DOI Numarası | 10.22038/IJBMS.2021.55875.12499 |
| Özet |
| Objective (s):The present study aimed to investigate the effects of periodontitis on kidneys and the protective role of crocin in periodontitis-induced kidney damage.Materials and Methods:Ethics committee approval was obtained and 30 Wistar rats were randomly divided into 3 groups of 10 rats: Control (C), Periodontitis (P), and Periodontitis+ Crocin (P+ Cr). After the treatments, rat kidney tissues were incised under anesthesia and blood samples were collected. Biochemical and histopathological analyses were conducted on the samples.Results:Malondialdehyde (MDA), total oxidant status (TOS), and oxidative stress index (OSI) increased in P group rat kidney tissues; urea, creatinine, Tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and interleukin 1β (IL-1β) levels increased in the serum; glutathione (GSH), superoxide dismutase (SOD), catalase (CAT) and total antioxidant status (TAS) levels were reduced in … |
| Anahtar Kelimeler |
| Crocin | Inflammation | Kidney damage | Oxidative stress | Periodontitis | Rat |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| WoS | 23 |
| Google Scholar | 27 |