Ameliorative effects of crocin on tartrazine dye–induced pancreatic adverse effects: a biochemical and histological study
Yazarlar (6)
Zeynep Erdemli
Eyüp Altınöz Karabük Üniversitesi, Türkiye
Prof. Dr. Mehmet Erman Erdemli İnönü Üniversitesi, Türkiye
Prof. Dr. Mehmet Gül İnönü Üniversitesi, Türkiye
Prof. Dr. Harika Gözde Gözükara Bağ İnönü Üniversitesi, Türkiye
Dr. Öğr. Üyesi Semir GÜL İnönü Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH (Q2) | ||
| Dergi ISSN | 0944-1344 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2021 |
| Cilt / Sayı / Sayfa | 28 / 2 / 2209–2218 | DOI | 10.1007/s11356-020-10578-6 |
| Makale Linki | http://link.springer.com/10.1007/s11356-020-10578-6 | ||
| UAK Araştırma Alanları |
Tıbbi Biyokimya
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| Özet |
| The present study aimed to analyze the impact of tartrazine (T) and crocin (Cr) applications on the pancreas tissues of the Wistar rats. A total of 40 Wistar rats were randomly divided into 4 groups with 10 rats in each group, including the Control, T, Cr, and T + Cr groups. After 3 weeks of application, the pancreatic tissues of the rats were removed under anesthesia and rat blood samples were obtained. Tissues were analyzed with biochemical and histopathological methods. It was determined that T administration increased malondialdehyde (MDA), total oxidant status (TOS), oxidative stress index (OSI), glucose, triglyceride, LDL, VLDL, and total cholesterol levels. However, it decreased reduced glutathione (GSH), total antioxidant status (TAS), superoxide dismutase (SOD), catalase (CAT), and HDL levels when compared with the other groups. It was observed that Cr administration significantly increased GSH, SOD … |
| Anahtar Kelimeler |
| Tartrazine | Pancreas | Crocin | Oxidative stress | Rat |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 15 |
| Google Scholar | 35 |