Effects of larazotide acetate, a tight junction regulator, on the liver and intestinal damage in acute liver failure in rats
Yazarlar (13)
Türkiye
İnönü Üniversitesi, Türkiye
Türkiye
Türkiye
Türkiye
Türkiye
Dr. Öğr. Üyesi Semir GÜL
İnönü Üniversitesi, Türkiye
Türkiye
Türkiye
Türkiye
| Makale Türü |
Özgün Makale
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| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | Human & Experimental Toxicology |
| Dergi ISSN | 0960-3271 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q3 |
| Makale Dili | İngilizce |
| Basım Tarihi | 11-2021 |
| Cilt No | 40 |
| Sayı | 12 |
| Sayfalar | 693 / 701 |
| DOI Numarası | 10.1177/09603271211058882 |
| Makale Linki | http://dx.doi.org/10.1177/09603271211058882 |
| Özet |
| Background and AimThe epithelial cells are the strongest determinants of the physical intestinal barrier. Tight junctions (TJs) hold the epithelial cells together and allow for selective paracellular permeability. Larazotide acetate (LA) is a synthetic octapeptide that reduces TJ permeability by blocking zonulin receptors. In this study, we aimed to investigate the effects of LA, a TJ regulator, on the liver and intestinal histology in the model of acute liver failure (ALF) in rats.Materials and MethodsThe thioacetamide (TAA) group received intraperitoneal (ip) injections of 300 mg/kg TAA for 3 days. The TAA+LA(dw) (drinking water) group received prophylactic 0.01 mg/mL LA orally for 7 days before the first dose of TAA. The LA(dw) group received 0.01 mg/mL LA orally. The TAA + LA(g) (gavage) group received prophylactic 0.01 mg/mL LA via oral gavage for 7 days before the first dose of TAA. The LA(g) group received 0.01 mg … |
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BM Sürdürülebilir Kalkınma Amaçları
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| Google Scholar | 7 |