Neuroprotection against CCl4 induced brain damage with crocin in Wistar rats
Yazarlar (8)
Karabük Üniversitesi, Türkiye
Niğde Ömer Halisdemir Üniversitesi, Türkiye
İnönü Üniversitesi, Türkiye
İnönü Üniversitesi, Türkiye
Dr. Öğr. Üyesi Semir GÜL
İnönü Üniversitesi, Türkiye
İnönü Üniversitesi, Türkiye
İnönü Üniversitesi, Türkiye
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | Biotechnic Histochemistry |
| Dergi ISSN | 1052-0295 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI |
| Dergi Grubu | Q4 |
| Makale Dili | İngilizce |
| Basım Tarihi | 10-2018 |
| Cilt No | 93 |
| Sayı | 8 |
| Sayfalar | 623 / 631 |
| DOI Numarası | 10.1080/10520295.2018.1519725 |
| Makale Linki | https://www.tandfonline.com/doi/full/10.1080/10520295.2018.1519725 |
| Özet |
| Owing to its lipophilic property, carbon tetrachloride (CCl) is rapidly absorbed by both the liver and brain. We investigated the protective effects of crocin against brain damage caused by CCl. Fifty rats were divided into five groups of ten: control, corn oil, crocin, CCl and CCl + crocin. CCl administration decreased glutathione (GSH) and total antioxidant status (TAS) levels, and catalase (CAT) activity, while significant increases were observed in malondialdehyde (MDA) and total oxidant status (TOS) levels and superoxide dismutase (SOD) activity. The cerebral cortex nuclear lamina developed a spongy appearance, neuronal degeneration was observed in the hippocampus, and heterochromatic and pyknotic neurons with increased cytoplasmic eosinophilia were observed in the hippocampus after CCl treatment. Because crocin exhibits strong antioxidant properties, crocin treatment increased GSH and TAS levels and CAT activities, and decreased MDA and TOS levels and SOD activity; significant improvements also were observed in histologic architecture. We found that crocin administration nearly eliminated CCl induced brain damage by preventing oxidative stress. |
| Anahtar Kelimeler |
| Brain damage | carbon tetrachloride | catalase | crocin | glutathione | malondialdehyde | oxidative stress |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| WoS | 19 |
| Google Scholar | 30 |