Crocin protects intestine tissue against carbon tetrachloride-mediated oxidative stress in rats
Yazarlar (7)
Binnaz Coşgun
Prof. Dr. Mehmet Erman Erdemli Niğde Ömer Halisdemir Üniversitesi, Türkiye
Prof. Dr. Mehmet Gül İnönü Üniversitesi, Türkiye
Dr. Öğr. Üyesi Semir GÜL İnönü Üniversitesi, Türkiye
Prof. Dr. Harika Gözde Gözükara Bağ İnönü Üniversitesi, Türkiye
Zeynep Aksungur
İnönü Üniversitesi, Türkiye
İnönü Üniversitesi, Türkiye
Eyüp Altınöz Karabük Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | GENERAL PHYSIOLOGY AND BIOPHYSICS (Q4) | ||
| Dergi ISSN | 0231-5882 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI | ||
| Makale Dili | İngilizce | Basım Tarihi | 07-2018 |
| Cilt / Sayı / Sayfa | 37 / 4 / 399–409 | DOI | 10.4149/gpb_2017057 |
| Makale Linki | http://www.elis.sk/index.php?page=shop.product_detailsflypage=flypage.tplproduct_id=5766category_id=143option=com_virtuemart | ||
| UAK Araştırma Alanları |
Histoloji ve Embriyoloji
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| Özet |
| Saffron is used in traditional medicine for its hypolipidemic, anti-inflammatory and anticarcinogenic properties as a natural remedy in treatment of diseases. The objective of the present study was to demonstrate the protective effect of crocin (one of the main ingredients of saffron) on carbon tetrachloride (CCl4) damage in intestinal mucosa. MDA, GSH, SOD, CAT, TAS and TOS levels were measured in experimental animal tissue samples and these were compared with histologic lesions induced by CCl4. CCl4 caused an increase in MDA, SOD, CAT and TOS levels and a significant decrease in GSH and TAS levels in rat intestinal tracts. After crocin treatment, serious improvements were observed in histological lesions and biochemical results in the intestinal tract. In conclusion, crocin inhibited the toxic effects induced by CCl4 in the intestine by its strong antioxidant properties. |
| Anahtar Kelimeler |
| CCl4 | Crocin | Oxidative stress | MDA | Intestine |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 10 |
| Google Scholar | 13 |