Can crocin play a preventive role in Wistar rats with carbon tetrachloride-induced nephrotoxicity?
Yazarlar (6)
Prof. Dr. Mehmet Erman Erdemli Niğde Ömer Halisdemir Üniversitesi, Türkiye
Prof. Dr. Mehmet Gül İnönü Üniversitesi, Türkiye
Eyüp Altınöz Karabük Üniversitesi, Türkiye
Zeynep Aksungur
Türkiye
Türkiye
Dr. Öğr. Üyesi Semir GÜL İnönü Üniversitesi, Türkiye
Prof. Dr. Harika Gözde Gözükara Bağ İnönü Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES (Q4) | ||
| Dergi ISSN | 2008-3866 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 04-2018 |
| Cilt / Sayı / Sayfa | 21 / 4 / 382–387 | DOI | 10.22038/IJBMS.2018.26101.6412 |
| Makale Linki | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5960754/ | ||
| UAK Araştırma Alanları |
Histoloji ve Embriyoloji
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| Özet |
| Objective(s): To investigate protective role of crocin by attempting to create nephrotoxicity with carbon tetrachloride. Materials and Methods Ethics committee approval was obtained and 50 male Wistar rats were randomly divided into 5 groups that included 10 rats each: Control, Corn oil, Crocin, Carbon tetrachloride (CCl4), and Crocin + Carbon tetrachloride. Following the experiments, the rats were decapitated under anesthesia and incised kidney tissues were subjected to biochemical and histological examinations. Results In the CCl4 administered group, MDA, TOS, Bun, and creatinine levels increased, GSH, SOD, CAT, and TAS levels decreased (P≤0.05), glomerular collapse in kidney sections, narrowing and local occlusion in Bowman’s space in certain glomeruli, inflammatory cell infiltration and congestion were observed when compared to all other groups. There was a significant decrease in increased MDA … |
| Anahtar Kelimeler |
| Crocin | Carbon tetrachloride | Kidney | Oxidative stress | Rat |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 15 |
| Google Scholar | 23 |