Thymoquinone is protective against 2,3,7,8-tetrachlorodibenzo-p-dioxin induced hepatotoxicity
Yazarlar (6)
Prof. Dr. Mehmet Erman Erdemli Niğde Ömer Halisdemir Üniversitesi, Türkiye
Birgül Yiğitcan
Prof. Dr. Mehmet Gül İnönü Üniversitesi, Türkiye
Prof. Dr. Harika Gözde Gözükara Bağ İnönü Üniversitesi, Türkiye
Dr. Öğr. Üyesi Semir GÜL İnönü Üniversitesi, Türkiye
Zeynep Aksungur
İnönü Üniversitesi, Türkiye
İnönü Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
|
||
| Dergi Adı | BIOTECHNIC & HISTOCHEMISTRY (Q4) | ||
| Dergi ISSN | 1052-0295 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2018 |
| Cilt / Sayı / Sayfa | 93 / 6 / 453–462 | DOI | 10.1080/10520295.2018.1453549 |
| Makale Linki | https://www.tandfonline.com/doi/full/10.1080/10520295.2018.1453549 | ||
| UAK Araştırma Alanları |
Histoloji ve Embriyoloji
|
||
| Özet |
| We investigated changes in rat liver tissues following administration of thymoquinone (TQ) against 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induced hepatotoxicity. Fifty rats were assigned randomly to five groups of 10 as follows: control, corn oil, TCDD, TQ and TCDD + TQ. Biochemical and histopathological analyses were conducted on liver tissue. We found that 30 day TCDD administration caused histopathological changes in liver including thickening of Glisson’s capsule, intracytoplasmic vacuolization in hepatocytes, sinusoidal dilation, vascular and sinusoidal congestion and inflammatory cell infiltration. TCDD administration increased malondialdehyde (MDA), total oxidant status (TOS), alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) levels in rat liver tissue and reduced glutathione (GSH), superoxide dismutase (SOD), catalase (CAT) and total antioxidant … |
| Anahtar Kelimeler |
| hepatotoxicity | liver | oxidative stress | 2 | 3 | 7 | 8-tetrachlorodibenzo-p-dioxin | thymoquinone |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 21 |
| Google Scholar | 30 |