Ischemia/reperfusion in rat: Antioxidative effects of enoant on EEG, oxidative stress and inflammation
Yazarlar (8)
Ihsan Kara
Istanbul Üniversitesi, Türkiye
Istanbul Üniversitesi, Türkiye
Prof. Dr. Asiye Nurten Istanbul Yeni Yüzyil Üniversitesi, Türkiye
Makbule Aydin
Istanbul Üniversitesi, Türkiye
Istanbul Üniversitesi, Türkiye
Prof. Dr. Elif Özkök Istanbul Üniversitesi, Türkiye
Ilknur Ozen
Lunds Universitet, İsveç
Lunds Universitet, İsveç
Bilge Ozerman
İstanbul Tıp Fakültesi, Türkiye
İstanbul Tıp Fakültesi, Türkiye
Dr. Öğr. Üyesi Sevilcan GAZİ Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Prof. Dr. Sacit Karamürsel Koç Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Brain Injury (Q4) | ||
| Dergi ISSN | 0269-9052 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI | ||
| Makale Dili | Ingilizce | Basım Tarihi | 01-2011 |
| Cilt / Sayı / Sayfa | 25 / 1 / 113–126 | DOI | 10.3109/02699052.2010.531688 |
| UAK Araştırma Alanları |
Histoloji ve Embriyoloji
|
||
| Özet |
| Primary objective: The present study was undertaken to evaluate whether enoant, which is rich in polyphenols, has any effect on electroencephalogram (EEG), oxidative stress and inflammation in ischemia/reperfusion (I/R) injury.Methods: Ischemia was induced by 2-hour occlusion of bilateral common carotid artery. Animals orally received enoant. Group 1 was the ischemic control group. Group 2 was treated with enoant of 1.25 g kg−1 per day for 15 days after I/R. Group 3 received the same concentration of enoant as in group 2 for 15 days before and after I/R. Group 4 was the sham operation group. EEG activities were recorded and the levels of TNF-α, IL-1β and IL-6, TBARS and GSH were measured in the whole brain homogenate.Results: There were significant changes in EEG activity in groups treated with enoant either before or after ischemia when compared with their basal EEG values. TNF-α, IL-6 and IL … |
| Anahtar Kelimeler |
| EEG | Inflammation | Ischemia/reperfusion | Oxidative stress | Polyphenols |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 9 |
| Scopus | 10 |
| Google Scholar | 17 |