The relationship between CYP2C9 gene polymorphisms and upper gastrointestinal bleeding in patients who used warfarin
Yazarlar (4)
Erciyes Üniversitesi, Türkiye
Doç. Dr. Şafak ŞAHİN
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Çanakkale Onsekiz Mart Üniversitesi, Türkiye
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SCOPUS dergilerinde yayınlanan tam makale |
| Dergi Adı | Medicinski Glasnik |
| Dergi ISSN | 1840-0132 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | Scopus |
| Makale Dili | İngilizce |
| Basım Tarihi | 01-2013 |
| Cilt No | 10 |
| Sayı | 1 |
| Sayfalar | 50 / 4 |
| Özet |
| Aim Oral anticoagulants are the most common used substance for treatment and prophylaxis of warfarin venous and arterial thromboembolic disorders in the world. Therapeutic index of warfarin is narrow. CYP2C9 is a hepatic microsomal enzyme and has a primary role in metabolism of warfarin and genetic variations of CYP2C9 may cause a serious effect on the response to warfarin in patients. The aim of this study was to determine the efficiency of CYP2C9 gene polymorphisms on drug metabolism in patients who had upper gastrointestinal system bleeding while using warfarin. |
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