EVALUATION OF NEUTROPHIL TO LYMPHOCYTE RATIO AS AN INDICATOR OF PRESENCE OF CORONARYARTERY DISEASE IN DIABETIC PATIENTS
Yazarlar (5)
Doç. Dr. Şafak ŞAHİN
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Bozok Üniversitesi, Türkiye
Ondokuz Mayıs Üniversitesi, Türkiye
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Doç. Dr. Kayıhan KARAMAN
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
| Makale Türü | Özgün Makale |
| Makale Alt Türü | Uluslararası alan indekslerindeki dergilerde yayınlanan tam makale |
| Dergi Adı | NATIONAL JOURNAL OF MEDICAL RESEARCH |
| Dergi Tarandığı Indeksler | Index Copernicus International |
| Makale Dili | İngilizce |
| Basım Tarihi | 01-2013 |
| Özet |
| Introduction: Cardiovascular disease (CVD) is the leading cause of death in type 2 diabetes mellitus (DM). DM is a substantial risk factor in atherosclerotic cardiovascular disease. We aimed to investigate relationship between the presence of established neutrophil to lymphocyte ratio (NLR) and coronary artery disease (CAD) in DM.Methods: 104 diabetic patients who had coronary lesion with a diameter stenosis of at least 50% and 64 diabetic patients who had normal coronary anatomy matched with age and sex were retrospectively selected and classified CAD (+) and CAD (-) group respectively. Baseline NLR in two groups was compared.Results: NLR was higher in CAD (+) group compared to group without CAD (-)(2.69±1.74 vs. 1.98±. 85, p< 0.001). C reactive protein (CRP) was higher in CAD (+) group compared to group without CAD (-)(1.71±99 vs. 1.38±. 99 p= 0.02). Multivariate analysis indicated CRP and NLR were an independent indicator of presence of CAD in diabetic patients (Odds ratio: 1.405,% CI: 1.035-1.908, p= 0.029 and odds ratio: 1.759,% CI: 1.226-2.525, p= 0.002 respectively).Conclusion: NLR was higher in diabetic patients with angiographically proven CAD compared to those without CAD. NLR may be a useful marker to predict the presence of CAD in type 2 diabetic patients. |
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