Neonatal Thrombocytopenia and the Role of the Platelet Mass Index in Platelet Transfusion in the Neonatal Intensive Care Unit
Yazarlar (8)
Doç. Dr. Tuba KASAP Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Şahin Takcı Ondokuz Mayıs Üniversitesi, Türkiye
Burcu Özge Erdoğan
Ankara Üniversitesi, Türkiye
Ankara Üniversitesi, Türkiye
Dr. Öğr. Üyesi Rüveyda GÜMÜŞER CİNNİ Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Ergün Sönmezgöz
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Prof. Dr. Ali GÜL Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Dr. Öğr. Üyesi Osman DEMİR Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Prof. Dr. Umut Safiye ŞAY COŞKUN Tokat Gaziosmanpaşa Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | BALKAN MEDICAL JOURNAL (Q4) | ||
| Dergi ISSN | 2146-3123 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 05-2020 |
| Cilt / Sayı / Sayfa | 37 / 3 / 150–156 | DOI | 10.4274/balkanmedj.galenos.2020.2019.7.47 |
| Makale Linki | http://balkanmedicaljournal.org/pdf.php?id=2183 | ||
| Özet |
| Background: Neonatal thrombocytopenia is a common hematologicalabnormality that occurs in 20–35% of all newborns in the neonatalintensive care unit. Platelet transfusion is the only known treatment;however, it is the critical point to identify neonates who are really atrisk of bleeding and benefit from platelet transfusion as it also hasvarious potential harmful effects.Aims: To investigate the prevalence and risk factors of neonatalthrombocytopenia and its relationship to intraventricular hemorrhagein the neonatal intensive care unit and to determine whether the useof platelet mass index-based criteria could reduce the rate of platelettransfusion.Study Design: Retrospective cohort study.Methods: This study was conducted in the neonatal intensive careunit of a tertiary university hospital. The medical records of neonatesin the neonatal intensive care unit with platelet counts <150×109/Lbetween January 2013 and July 2016 were analyzed.Results: During the study period, 2,667 patients were admitted to theneonatal intensive care unit, and 395 (14%) had thrombocytopeniaduring hospitalization. The rate of intraventricular hemorrhage was7.3%. Multiple logistic regression analysis showed that althoughlower platelet counts were associated with a higher intraventricularhemorrhage rate, the effects of respiratory distress syndrome, sepsis,and patent ductus arteriosus were more prominent than the degree ofthrombocytopenia. Thirty patients (7%) received platelet transfusion,and these patients showed a significantly higher mortality rate thantheir non-platelet transfusion counterparts (p<0.001). In addition, itwas found that the use of platelet mass index-based criteria for platelettransfusion in our patients would reduce the rate of platelet transfusionby 9.5% (2/21).Conclusion: Neonatal thrombocytopenia is usually mild and oftenresolves without treatment. As platelet transfusion is associated withan increased mortality rate, its risks and benefits should be weighedcarefully. The use of platelet mass index-based criteria may reduceplatelet transfusion rates in the neonatal intensive care unit, butadditional data from prospective studies are required |
| Anahtar Kelimeler |
| Intraventricular hemorrhage | neonatal intensive care unit | newborn | platelet mass index | platelet transfusion | thrombocytopenia |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 9 |