Anticholinergic, antidiabetic and antioxidant activities of cinnamon (cinnamomum verum) bark extracts: polyphenol contents analysis by LC-MS/MS
Yazarlar (10)
Ilhami Gulcin Atatürk Üniversitesi, Türkiye
Ruya Kaya
Atatürk Üniversitesi, Türkiye
Atatürk Üniversitesi, Türkiye
Ahmet C. Goren
Bezmiâlem Vakıf Üniversitesi, Türkiye
Bezmiâlem Vakıf Üniversitesi, Türkiye
Hulya Akincioglu Aǧrı İbrahim Çeçen Üniversitesi, Türkiye
Meryem Topal Gümüşhane Üniversitesi, Türkiye
Dr. Öğr. Üyesi Zeynebe BİNGÖL Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Kader Cetin Çakmak
Atatürk Üniversitesi, Türkiye
Atatürk Üniversitesi, Türkiye
Sevim B. Ozturk Sarikaya
Gümüşhane Üniversitesi, Türkiye
Gümüşhane Üniversitesi, Türkiye
Lokman Durmaz Erzincan Binali Yıldırım Üniversitesi, Türkiye
Saleh Alwasel
College Of Sciences, Suudi Arabistan
College Of Sciences, Suudi Arabistan
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | International Journal of Food Properties | ||
| Dergi ISSN | 1094-2912 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 08-2019 |
| Cilt / Sayı / Sayfa | 22 / 1 / 1511–1526 | DOI | 10.1080/10942912.2019.1656232 |
| Makale Linki | https://www.tandfonline.com/doi/full/10.1080/10942912.2019.1656232 | ||
| Özet |
| Ethanolic (EEC) and aqueous (WEC) extracts of cinnamon (Cinnamomum verum) were evaluated for their antioxidant profiles by eight distinguished bioanalytical antioxidant methods. Their inhibitory effects were tested against some enzymes including acetylcholinesterase, butyrylcholinesterase, α-glycosidase and α-amylase, which linked to different diseases. Additionally, the antioxidant properties were determined and polyphenolic compositions of the both extracts were evaluated by LC-MS/MS analysis. According to the LC-MS/MS experiments, thirteen compounds were found in WEC and EEC. Also, p-hydroxybenzoic acid (321.1 mg/kg extract), p-coumaric acid (291.4 mg/kg extract), and pyrogallol (142.4 mg/kg extract) were found to be the most abundant ingredients in the WEC. On the other hand, pyrogallol (264.3 mg/kg extract), ferulic acid (224.7 mg/kg extract) and p-coumaric acid (170.2 mg/kg extract) were found as the most plentiful chemicals in the EEC. For the estimation of the antioxidant capacities of the both extracts (WEC and EEC), DPPH· and ABTS•+ scavenging activities, as well as Fe3+-Fe2+, and Cu2+-Cu+ reducing assays were studied. The IC50 values of the WEC and EEC indicated that they were potent effective DPPH· (21. 25 and 15.71 μg/mL) and ABTS•+ (6.52 and 5.79 μg/mL) scavengers, as well as AChE (221.33 and 110.26 μg/mL), BChE (461.69 and 94.93 μg/mL), α-glycosidase (206.86 and 220.00 μg/mL) and α-amylase (189.86 and 200.86 μg/mL) inhibitors. As a conclusion, both EEC and WEC had rich phenolic contents and demonstrated effective anticholinergic, antidiabetic and antioxidant effects. |
| Anahtar Kelimeler |
| antioxidant activity | Cinnamomum verum | Cinnamon | LC-MS/MS | polyphenol content |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| WoS | 153 |
| SCOPUS | 181 |
| Google Scholar | 218 |
| Google Scholar | 150 |