LC-HRMS Profiling and Antidiabetic, Anticholinergic, and Antioxidant Activities of Aerial Parts of Kınkor (Ferulago stellata)
Yazarlar (8)
Hatice Kızıltaş Yüzüncü Yıl Üniversitesi, Türkiye
Dr. Öğr. Üyesi Zeynebe BİNGÖL Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Ahmet Ceyhan Gören Bezm-İ Âlem Vakıf Üniversitesi, Türkiye
Leyla Polat Köse Beykent Üniversitesi, Türkiye
Lokman Durmaz Erzincan Binali Yıldırım Üniversitesi, Türkiye
Fevzi Topal Gümüşhane Üniversitesi, Türkiye
Saleh H. Alwasel
College Of Sciences, Suudi Arabistan
College Of Sciences, Suudi Arabistan
İlhami Gülçin Atatürk Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
|
||
| Dergi Adı | Molecules (Q2) | ||
| Dergi ISSN | 1420-3049 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2021 |
| Cilt / Sayı / Sayfa | 26 / 9 / 1–18 | DOI | 10.3390/molecules26092469 |
| Makale Linki | http://dx.doi.org/10.3390/molecules26092469 | ||
| Özet |
| Kınkor (Ferulago stellata) is Turkish medicinal plant species and used in folk medicine against some diseases. As far as we know, the data are not available on the biological activities and chemical composition of this medicinal plant. In this study, the phytochemical composition; some metabolic enzyme inhibition; and antidiabetic, anticholinergic, and antioxidant activities of this plant were assessed. In order to evaluate the antioxidant activity of evaporated ethanolic extract (EEFS) and lyophilized water extract (WEFS) of kınkor (Ferulago stellata), some putative antioxidant methods such as DPPH· scavenging activity, ABTS•+ scavenging activity, ferric ions (Fe3+) reduction method, cupric ions (Cu2+) reducing capacity, and ferrous ions (Fe2+)-binding activities were separately performed. Furthermore, ascorbic acid, BHT, and α-tocopherol were used as the standard compounds. Additionally, the main phenolic compounds that are responsible for antioxidant abilities of ethanol and water extracts of kınkor (Ferulago stellata) were determined by liquid chromatography-high-resolution mass spectrometry (LC-HRMS). Ethanol and water extracts of kınkor (Ferulago stellata) demonstrated effective antioxidant abilities when compared to standards. Moreover, ethanol extract of kınkor (Ferulago stellata) demonstrated IC50 values of 1.772 µg/mL against acetylcholinesterase (AChE), 33.56 ± 2.96 µg/mL against α-glycosidase, and 0.639 µg/mL against α-amylase enzyme respectively. |
| Anahtar Kelimeler |
| Acetylcholinesterase | Antioxidant activity | Ferulago stellata | Kınkor | LC-HRMS | Polyphenol content | α-amylase | α-glycosidase |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| WoS | 60 |
| SCOPUS | 63 |
| Google Scholar | 68 |