Anticholinergic, Antidiabetic and Antioxidant Activities of Ferula orientalis L. Determination of Its Polyphenol Contents by LC-HRMS
Yazarlar (5)
Hatice Kızıltaş Van Yüzüncü Yıl Üniversitesi, Türkiye
Ahmet C. Gören
Bezmiâlem Vakıf Üniversitesi, Türkiye
Bezmiâlem Vakıf Üniversitesi, Türkiye
Dr. Öğr. Üyesi Zeynebe BİNGÖL Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Saleh H. Alwasel
College Of Sciences, Suudi Arabistan
College Of Sciences, Suudi Arabistan
İlhami Gülçin Atatürk Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(Ulusal alan endekslerinde (TR Dizin, ULAKBİM) yayınlanan tam makale)
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| Dergi Adı | Records of Natural Products | ||
| Dergi ISSN | 1307-6167 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | TR DİZİN | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2021 |
| Cilt / Sayı / Sayfa | 15 / 6 / 513–528 | DOI | 10.25135/rnp.236.21.02.1983 |
| Makale Linki | http://dx.doi.org/10.25135/rnp.236.21.02.1983 | ||
| Özet |
| To evaluate the antioxidant activity of evaporated ethanolic extract of Ferula orientalis L. (EEFO) and lyophilized water extract of Ferula orientalis L. (WEFO) several in vitro antioxidant methods such as ABTS•+ scavenging activity, DPPH· scavenging activity, Fe3+reduction method, cupric ions (Cu2+) reduction capacity, and metal ion (Fe2+)-binding activities using ferrozine reagent were separately performed. Also, BHT, α-tocopherol and ascorbic acid were used as the standard antioxidant molecules. Moreover, some phenolic compounds that are responsible for antioxidant abilities of EEFO and WEFO were determined by LC-HRMS. EEFO and WEFO demonstrated effective antioxidant abilities when compared with the standards. EEFO demonstrated IC50 values of 1.946 µg/mL against acetylcholinesterase (AChE), 0.815 µg/mL against α-glycosidase, and 0.675 µg/mL against α-amylase |
| Anahtar Kelimeler |
| Acetylcholinesterase, αamylase | Antioxidant activity | Ferula orientalis | Phenolic compound | α-glycosidase |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| WoS | 66 |
| SCOPUS | 65 |
| TRDizin | 11 |
| Google Scholar | 69 |
| Google Scholar | 54 |