Screening of non-alkaloid acetylcholinesterase and carbonic anhydrase isoenzymes inhibitors of Leiotulus dasyanthus (K. Koch) Pimenov Ostr. (Apiaceae)
Yazarlar (6)
Songul Karakaya Atatürk Üniversitesi, Türkiye
Dr. Öğr. Üyesi Zeynebe BİNGÖL Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Mehmet Koca Atatürk Üniversitesi, Türkiye
Betül Demirci Anadolu Üniversitesi, Türkiye
Ilhami Gulcin Atatürk Üniversitesi, Türkiye
K. Hüsnü Can Baser
Yakın Doğu Üniversitesi, Kıbrıs Rum Kesimi
Yakın Doğu Üniversitesi, Kıbrıs Rum Kesimi
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Journal of Essential Oil Research (Q4) | ||
| Dergi ISSN | 1041-2905 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2020 |
| Cilt / Sayı / Sayfa | 32 / 3 / 227–241 | DOI | 10.1080/10412905.2020.1746415 |
| Özet |
| The oxidant, cholinesterase, and carbonic anhydrase inhibitions of essential oils and their major compounds of Leiotulus dasyanthus and molecular docking studies of α-pinene and δ-3-carene were evaluated in this study. Phenolic constituents and antioxidant activity of samples were determined by Folin-Ciocalteu’s, DPPH, and TBA processes. Cholinesterase inhibition effect was evaluated through Ellman’s method. GC-FID and GC/MS were used for analysing of essential oils. The root oil got the highest total phenolic content (898.87 mg/g). The utmost activity was shown flower oil (29.31 μg/mL) in the DPPH test. The root oil indicated considerable inhibition towards acetylcholinesterase (21.92%) and butyrylcholinesterase (91.33%) enzymes, respectively. α-pinene and δ-3-carene indicated high acetylcholinesterase inhibitory activity (66.44 and 48.71%, respectively). Cytosolic hCA I and II isoenzymes were influentially inhibited by flower and aerial part oils with 1.694 and 1.677 µM IC50 values, respectively. 1-Dodecanol (7.8%); β-pinene (63.3%), α-pinene (20.5%); octyl acetate (14.7%); hexyl octanoate (55.1%) were characterized as principle compounds of aerial parts, roots, flowers, and fruits respectively. |
| Anahtar Kelimeler |
| Anticholinesterase | antioxidant | carbonic anhydrase | leiotulus | pinene | δ-3-carene |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| WoS | 12 |
| SCOPUS | 11 |
| Google Scholar | 11 |
| Google Scholar | 11 |