Polyphenol Contents, Potential Antioxidant, Anticholinergic and Antidiabetic Properties of Mountain Mint (Cyclotrichium leucotrichum)
Yazarlar (6)
İlhami Gülçin Atatürk Üniversitesi, Türkiye
Dr. Öğr. Üyesi Zeynebe BİNGÖL Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Parham Taslimi Bartin Üniversitesi, Türkiye
Ahmet C. Gören
Gebze Teknik Üniversitesi, Türkiye
Gebze Teknik Üniversitesi, Türkiye
Saleh H. Alwasel
College Of Sciences, Suudi Arabistan
College Of Sciences, Suudi Arabistan
Ahmet Zafer Tel Iğdır Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Chemistry and Biodiversity (Q3) | ||
| Dergi ISSN | 1612-1872 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | Türkçe | Basım Tarihi | 01-2022 |
| Cilt / Sayı / Sayfa | 19 / 3 / – | DOI | 10.1002/cbdv.202100775 |
| Makale Linki | http://dx.doi.org/10.1002/cbdv.202100775 | ||
| Özet |
| In the present work, antioxidant and antidiabetic potentials of mountain mint [Cyclotrichium leu-cotrichum (Stapf ex Rech. Fil.) Leblebici] was the first time appraised. In this sense, methanol (MECL) and water (WECL) extracts were obtained from aerial parts of mountain mint (Cyclotrichium leucotrichum) and studied for their antioxidant ability by several bioanalytical assays. Also, their inhibition profiles were realized toward several metabolic enzymes connected to some diseases, including butyrylcholinesterase (BChE), α-glycosidase, acetylcholinesterase (AChE), and α-amylase enzymes. Additionally, their phenolic contents were determined by putative chromatographic method of LC/MS/MS. Consequently, nineteen phenolic molecules were identified in MECL and fifteen phenolic molecules were found in WECL. Also, antioxidant effects of both extracts were studied using by the methods of 1,1-diphenyl-2-picryl-hydrazyl (DPPH⋅), 2,2'-azinobis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS.+) and N,N-dimethyl-p-phenylenediamine (DMPD.+) scavenging activities, ferric (Fe3+) and cupric (Cu2+) ions and Fe3+-2,4,6-tri(2-pyridyl)-s-triazine (TPTZ) reducing capacities. MECL and WECL were found as powerful DPPH⋅ (IC50: 23.74 and 28.85 μg/mL), ABTS.+ (IC50: 12.53 and 14.05 μg/mL) and DMPD.+ scavenging effects (IC50: 43.52 and 54.80 μg/mL). Also, both extracts demonstrated the effective inhibition on AChE (IC50: 69.31 and 115.51 μg/mL), BChE (IC50: 57.75 and 86.62 μg/mL), α-glycosidase (IC50: 36.47 and 62.94 μg/mL) and α-amylase (IC50: 1.01 and 3.43 μg/mL). This study will be useful for future studies to determine the antioxidant properties and enzyme inhibition profile of food, medical and industrially important plants. |
| Anahtar Kelimeler |
| antioxidant activity | Cyclotrichium leucotrichum | enzyme inhibition | LC/MS/MS | polyphenol content |