Vinyl functionalized 5,6‐dimethylbenzimidazolium salts: Synthesis and biological activities
Yazarlar (5)
Emine Karaca Inönü Üniversitesi, Türkiye
Dr. Öğr. Üyesi Zeynebe BİNGÖL Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Nevin Gürbüz Inönü Üniversitesi, Türkiye
İsmail Özdemir Inönü Üniversitesi, Türkiye
İlhami Gülçin Atatürk Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Journal of Biochemical and Molecular Toxicology (Q2) | ||
| Dergi ISSN | 1095-6670 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | Türkçe | Basım Tarihi | 11-2022 |
| Cilt / Sayı / Sayfa | 37 / 2 / – | DOI | 10.1002/jbt.23255 |
| Makale Linki | http://dx.doi.org/10.1002/jbt.23255 | ||
| Özet |
| A series of vinyl functionalized 5,6-dimethylbenzimidazolium salts are synthesized. All compounds were fully characterized by elemental analyses, MS, 1H-NMR, 13C-NMR, and IR spectroscopy techniques. Enzyme inhibition is a very active area of research in drug design and development. In this study, the synthesized novel benzimidazolium salts were evaluated toward the human erythrocyte carbonic anhydrase I (hCA I), and II (hCA II) isoenzymes, acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes. They demonstrated highly potent inhibition ability against hCA I with Ki values of 484.8 ± 62.6–1389.7 ± 243.2 nM, hCA II with Ki values of 298.9 ± 55.7–926.1 ± 330.0 nM, α-glycosidase with Ki values of 170.3 ± 27–760.1 ± 269 μM, AChE with Ki values of 27.1 ± 3–77.6 ± 1.7 nM, and BChE with Ki values of 21.0 ± 5–61.3 ± 15 nM. As a result, novel vinyl functionalized 5,6-dimethylbenzimidazolium salts (1a–g) exhibited effective inhibition profiles toward studied metabolic enzymes. Therefore, we believe that these results may contribute to the development of new drugs particularly to treat some global disorders including glaucoma, Alzheimer's disease, and diabetes. |
| Anahtar Kelimeler |
| 5,6-dimethylbenzimidazolium salts, acetylcholinesterase | butyrylcholinesterase | carbonic anhydrase | enzyme inhibition | α-glycosidase |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| WoS | 9 |
| SCOPUS | 8 |
| Google Scholar | 9 |
| Google Scholar | 6 |